Product Details
DAPAGLIFLOZIN 10 MG + METFORMIN HYDROCHLORIDE 500 MG (SR)
Introduction : Dapagliflozin 10mg and Metformin 500mg SR (sustianed realease )combination is indicated for the management of type 2 diabetes mellitus. It helps improve glycemic control by reducing blood sugar levels through different mechanisms of action.
Dapagliflozin is used together with proper diet and exercise to treat type 2 diabetes. It works in the kidneys to prevent absorption of glucose (blood sugar).
Metformin works by decreasing the production of glucose in the liver, reducing intestinal glucose absorption, and increasing glucose uptake and utilization in peripheral tissues. Metformin SR (sustained-release) formulations release the medication gradually over time, allowing for once-daily dosing.
Indication : This Dapagliflozin 10mg and Metformin 500mg SR (sustianed realease ) medication is a combination of 2 drugs: dapagliflozin and metformin. It is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke.
This medication is also used to treat kidney disease or heart failure in people with type 2 diabetes. It helps to lower the risk of death from heart disease and reduces the need of going to a hospital to treat heart failure. This medication works by helping to restore your bodys proper response to the insulin you naturally produce. It also increases the removal of sugar by your kidneys, decreases how much sugar is made in your liver, and decreases how much sugar your body takes in through your stomach and intestines.
Administration : . It is typically taken orally, once daily, with a meal or as directed by a healthcare professional.
Swallow the tablet or extended-release tablet whole with a full glass of water. Do not crush, break, or chew it.
While taking the extended-release tablet, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.
Storage : Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Side Effects : Common side effects may include urinary tract infections, genital yeast infections, increased urination, diarrhea, nausea, vomiting, headache, or dizziness, difficulty in urination
Contraindications : Acute or chronic metabolic acidosis including diabetic ketoacidosis
Severe renal impairment
Avoid use of this drug during pregnancy and prescribe an alternative. Evidence has demonstrated fetal abnormalities or risks when used during pregnancy. Advise women of childbearing potential of fetal risk.
Safety Advice / Warnings : Avoid alcohol and tobaccco consumption while taking this medicnes
Hyperglycemia (high blood sugar) may occur if you do not take enough or skip a dose of your medicine, overeat or do not follow your meal plan, have a fever or infection, or do not exercise as much as usual. High blood sugar can be very serious and must be treated right away. It is important that you learn which symptoms you have in order to treat it quickly. Talk to your doctor about the best way to treat high blood sugar.
Dizziness, lightheadedness, or fainting may occur with this medicine. Drink plenty of water during exercise or in hot weather. Check with your doctor if you have severe nausea, vomiting, or diarrhea that does not stop. This may cause you to lose too much water.
References : Product Information: GLUCOPHAGE(R) oral tablets, metformin HCl oral tablets. Bristol-Myers Squibb Company (per FDA), Princeton, NJ, 2017.
Product Information: Metformin Juta oral tablet, metformin hydrochloride oral tablet. Juta Pharma GmbH (per AEMPS;Spain), Gutenbergstrasse 13, 24941 Flensburg, Germany, 2019.
Product Information: FORXIGA(R) oral tablets, dapagliflozin oral tablets. AstraZeneca Pharmaceuticals LP (per manufacturer), Wilmington, DE, 2021.
Dandona P, Mathieu C, Phillip M, et al: Efficacy and safety of dapagliflozin in patients with inadequately controlled type 1 diabetes (DEPICT-1): 24 week results from a multicentre, double-blind, phase 3, randomised controlled trial. Lancet Diabetes Endocrinol 2017; 5(11):864-876.
Mechanism of Action : Dapagliflozin 10 mg: Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It works by inhibiting SGLT2 in the kidneys, which reduces glucose reabsorption and promotes the excretion of glucose in the urine. This helps lower blood sugar levels in people with type 2 diabetes.
Metformin Hydrochloride 500 mg SR: Metformin is a biguanide antidiabetic medication. It works by decreasing the production of glucose in the liver, reducing intestinal glucose absorption, and increasing glucose uptake and utilization in peripheral tissues. Metformin SR (sustained-release) formulations release the medication gradually over time, allowing for once-daily dosing.
Therapeutic : Anti Diabetic