Product Details
GLICLAZIDE 40 MG + METFORMIN HYDROCLORIDE 500 MG + VOGLIBOSE 0.2 MG
Introduction : Gliclazide 40 Mg + Metformin Hydrocloride 500 Mg + Voglibose 0.2 Mg tablet is commonly prescribed for the management of type 2 diabetes mellitus. Each component of the combination works in different ways to help control blood sugar levels:
Gliclazide is a sulfonylurea medication that stimulates the release of insulin from the pancreas, thereby lowering blood sugar levels.
Metformin is a biguanide medication that reduces glucose production in the liver, improves insulin sensitivity, and enhances glucose uptake by muscle cells.
Voglibose is an alpha-glucosidase inhibitor that slows down the absorption of carbohydrates from the digestive tract, resulting in lower post-meal blood sugar levels.
Indication : High blood sugar levels after meals, is a common problem in individuals with diabetes. Gliclazide 40 mg + Metformin Hydrochloride 500 mg + Voglibose 0.2 mg combination medication is particularly effective in controlling postprandial hyperglycemia. Voglibose, an alpha-glucosidase inhibitor, delays the digestion and absorption of carbohydrates from the gut, thereby reducing the rise in blood sugar levels after meals.
This medication is prescribed for the management of type 2 diabetes mellitus. It helps control blood sugar levels by addressing multiple aspects of glucose metabolism.
Administration : It is typically taken orally, usually once or twice daily, with meals.
Tablets are for oral use. Take your tablet(s) with a glass of water (and preferably at the same time each day). Swallow
your tablets whole. Do not chew them.
Storage : Keep this medicine out of the sight and reach of children.
? Do not store above 25C. Store in the original package
Side Effects : Hypoglycemia (low blood sugar)
Gastrointestinal discomfort (such as nausea, diarrhea, or abdominal pain)
Weight gain (less common with metformin)
Headache
Dizziness
Skin rash or itching
Hypersensitivity reactions (rare)
Contraindications : "If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this
medicine.
You must not take this medicine while you are breast-feeding"
Safety Advice / Warnings : This medicine be used with caution in elderly patients, as they may be more susceptible to hypoglycemia and other adverse effects.
Patients should be advised to avoid excessive alcohol consumption while taking Gliclazide, as alcohol may potentiate the risk of hypoglycemia.
Tablets are not recommended for use during pregnancy.
If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this
medicine.
You must not take this medicine while you are breast-feeding
Drinking alcohol is not recommended as it can alter the control of your diabetes in an unpredictable manner"
References : https://www.drugs.com/uk/pdf/leaflet/1084506.pdf (Zircon product leaflet)
"Voglibose - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2021 [cited 03 December 2021]. Available from:
https://pubchem.ncbi.nlm.nih.gov/compound/444020
Bressler R & Johnson DG: Pharmacological regulation of blood glucose levels in non-insulin-dependent diabetes mellitus. Arch Intern Med 1997; 157:836-848.
Mechanism of Action : Gliclazide stimulates the release of insulin from the pancreas, which helps to lower blood sugar levels.
Metformin reduces glucose production in the liver, increases insulin sensitivity in peripheral tissues, and decreases intestinal glucose absorption.
Voglibose inhibits alpha-glucosidase enzymes in the intestines, delaying the digestion and absorption of carbohydrates, thereby reducing postprandial blood sugar levels.
Therapeutic : Anti Diabetic