Product Details
ACECLOFENAC 100 MG + PARACETAMOL 325 MG + CHLORZOXAZONE 250 MG
Introduction : Aceclofenac, Chlorzoxazone, and Paracetamol Tablet is a pharmaceutical formulation that combines three active ingredients to provide relief from pain, inflammation, and muscle spasms.
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, substances in the body that cause pain and inflammation. It is known for its analgesic (pain-relieving) and anti-inflammatory properties, making it effective in alleviating various types of pain, including musculoskeletal pain, arthritis, and dental pain.
Chlorzoxazone is a muscle relaxant that acts directly on the central nervous system to relieve muscle spasms and stiffness. It works by inhibiting the reflexes in the spinal cord, reducing muscle contractions and promoting muscle relaxation. This helps in easing the discomfort associated with muscle spasms, strains, sprains, and other muscular conditions.
Paracetamol, also known as acetaminophen, is a widely used analgesic and antipyretic (fever-reducing) medication. It works by inhibiting the production of prostaglandins in the brain, which helps to lower pain and reduce fever. Paracetamol is effective in relieving mild to moderate pain, including headaches, toothaches, menstrual cramps, and general body aches.
Indication : Aceclofenac (100 mg):
Indications: Used for the relief of pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Paracetamol (325 mg):
Indications:Used for the relief of mild to moderate pain and fever.
Chlorzoxazone (250 mg):
Indications: Used for the relief of muscle spasms and discomfort.
Indications for Combination:
- This combination medication is often prescribed for conditions where pain, inflammation, and muscle spasms coexist. Conditions such as musculoskeletal pain, sprains, and strains may benefit from the combined effects of these three components.
Administration : Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. this Tablet may be preferrably taken with food or after food
Storage : Store at controlled room temperature, 20 to 25 degrees C . in a well-closed container; protect from light
Side Effects : Possible side effects of Aceclofenac, Chlorzoxazone, and Paracetamol Tablets may include:
Gastrointestinal issues (stomach pain, indigestion, nausea, diarrhoea).
Dizziness or drowsiness.
Skin reactions (rash, itching).
Liver or kidney effects with prolonged use.
Contraindications : - Individuals with a history of allergic reactions to NSAIDs, paracetamol, or muscle relaxants should exercise caution.
- This combination is generally contraindicated in patients with severe liver or kidney impairment.
Safety Advice / Warnings : "Avoid the consumption of alcohol while taking Aceclofenac Tablet as it will increase the risk of stomach bleeding.
Patients with a history of gastrointestinal ulcers, bleeding disorders, kidney impairment, liver dysfunction, or cardiovascular disease should use aceclofenac with caution.
This tablet is not recommended for use during pregnancy especially in the third trimester (last 3 months)
this Tablet SR may cause sleepiness, blurred vision, or dizziness in some cases. Avoid driving vehicles or operating heavy machines if you experience such symptoms after taking this medicine."
References : Micromedex Solutions. Drug Information Database.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137632/
https://www.sciencedirect.com/topics/neuroscience/chlorzoxazone
Mechanism of Action : Chlorzoxazone is a muscle relaxant. It acts by blocking nerve impulses or pain sensations that are sent to brain. Typically, it is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.
Aceclofenac is a nonsteroidal phenylacetic acid derivative related to diclofenac. Like other nonsteroidal antiinflammatory drugs (NSAIDS), aceclofenac is a prostaglandin synthetase (cyclooxygenase) inhibitor, which decreases prostaglandin and leukotriene production, therefore inhibiting the inflammatory process.