Product Details
LOSARTAN 50 MG + AMLODIPINE 5 MG
Introduction : Losartan 50 Mg & Amlodipine 5 Mg combination tablets are indicated for the treatment of hypertension in adults who require combination therapy to achieve blood pressure control.
Losartan works by blocking a substance in the body that causes the blood vessels to tighten. As a result,Losartan relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.
Amlodipine is a type of medicine known as a calcium channel blocker (CCB). It is used to treat high blood pressure (hypertension) and a type of chest pain called angina.
Indication : Losartan 50 Mg + Amlodipine 5 Mg tablet is indicated for:
Treatment of Hypertension: The combination medication is used to lower blood pressure in individuals with hypertension (high blood pressure). It is particularly beneficial for patients whose blood pressure is not adequately controlled with monotherapy or who require combination therapy to achieve target blood pressure levels.
Cardiovascular Risk Reduction: In addition to lowering blood pressure, the combination of Losartan and Amlodipine may also provide cardiovascular protective effects. By reducing blood pressure and improving vascular function, this medication may help lower the risk of cardiovascular events such as heart attacks, strokes, and other complications associated with hypertension.
Administration : This medicine may be taken with or without food.
In addition to taking this medicine, treatment for your high blood pressure may include weight control and a change in the foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you.
Storage : Protect from moisture or light and store below 30 degrees Celsius (C))
Side Effects : dizziness, headache, swelling of the ankles or feet, flushing, and fatigue.
Contraindications : "Evidence has demonstrated fetal abnormalities or risks when used during pregnancy and breast feeding. consult with doctor immidaitely
Safety Advice / Warnings : Using this medicine while you are pregnant can harm your unborn baby.
Dizziness or lightheadedness may occur after the first dose of this medicine, especially if you have been taking a diuretic (water pill). Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy.
Check with your doctor right away if you become sick while taking this medicine, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water, and may lead to low blood pressure. You can also lose water by sweating, so drink plenty of water during exercise or in hot weather.
Severe, chronic diarrhea with weight loss may develop months to years after taking this medicine. Tell your doctor right away if you have these symptoms.
Ask your doctor before you use medicines, supplements, or salt substitutes that contain potassium.
References : Pedro AA, Gehr TWB, Brophy DF, et al: Pharmacokinetics and pharmacodynamics of losartan in continuous ambulatory peritoneal dialysis. J Clin Pharmacol 2000; 40:389-395.
Product Information: COZAAR(R) oral tablets, losartan potassium oral tablets. Merck Sharp & Dohme Corp. (per FDA), Whitehouse Station, NJ, 2015.
AMLODIPINE/OLMESARTAN MEDOXOMIL
Amlodipine besylate [FDA Label]. New York, NY: Pfizer Labs.; 1987 [revised May 2011].
Mechanism of Action : Losartan is an orally active, nonpeptide angiotensin II receptor blocker (ARB), selective for the AT1 receptor. It blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor subtype in many tissues (eg, vascular smooth muscle, adrenal gland). It has no agonist activity of AT1 and its affinity for the AT1 receptor is approximately 1000 times greater than for the AT2 receptor
Amlodipine is a calcium channel blocker (CCB) that works by relaxing the blood vessels, allowing blood to flow more easily and reducing blood pressure.
Therapeutic : Cardiovascular Agent