Product Details
ONDANSETRON 4 MG MD
Introduction : Ondansetron 4mg tablet is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation therapy. It is also used to prevent nausea and vomiting that may occur after surgery. Ondansetron works in the stomach to block the signals to the brain that cause nausea and vomiting.
This medicine is available only with your doctors prescription.
Indication : Ondansetron 4mg tablets are indicated for the following conditions:
Chemotherapy-Induced Nausea and Vomiting (CINV): Ondansetron is frequently used to prevent and manage nausea and vomiting caused by chemotherapy treatments for cancer.
Radiation Therapy-Induced Nausea and Vomiting (RINV): It may also be used to prevent nausea and vomiting associated with radiation therapy.
Postoperative Nausea and Vomiting (PONV): Ondansetron is sometimes administered before or after surgery to reduce the risk of postoperative nausea and vomiting.
Administration : To use the oral disintegrating tablet:
-Make sure your hands are dry.
-Do not push the tablet through the foil backing of the package. Instead, gently peel back the foil backing and remove the tablet.
-Immediately place the tablet on top of the tongue. The tablet will dissolve in seconds, and you may swallow it with your saliva.
-You do not need to drink water or other liquid to swallow the tablet.
To use the oral soluble film:
-Make sure your hands are clean and dry before and after using this medicine.
-remove the film coated tablet out from the strip.
-Put the soluble film immediately on top of your tongue where it will dissolve in 4 to 20 seconds. Do not chew or swallow the film whole.
-Once the film is dissolved, you may swallow with or without water.
If you vomit within 30 minutes after using this medicine, take the same amount of medicine again. If vomiting continues, check with your doctor.
Storage : Store at room temperature away from moisture and heat.
Mechanism of Action : Ondansetron is a selective serotonin 5-HT3 receptor antagonist. It works by blocking serotonin receptors in the chemoreceptor trigger zone (CTZ) of the brain and the gastrointestinal tract, thereby reducing the sensation of nausea and suppressing the vomiting reflex
Therapeutic : Antiemetic
Side Effects : Confusion; dizziness; fast heartbeat; fever; headache; trouble breathing
Contraindications : Evidence has demonstrated fetal abnormalities or risks when used during pregnancy. Use with preaution
Safety Advice / Warnings : Check with your doctor right away if you start to have pain or swelling in your stomach area. These may be signs of a serious stomach or bowel problem.
This medicine may make you dizzy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
References : Product Information: ZUPLENZ(R) oral soluble film, ondansetron oral soluble film. Strativa Pharmaceuticals, Woodcliff Lake, NJ, 2010.
Freedman SB, Adler M, Seshadri R, et al: Oral ondansetron for gastroenteritis in a pediatric emergency department. N Engl J Med 2006; 354(16):1698-1705.
Product Information: SANDOZ ONDANSETRON ODT oral disintegrating tablets, ondansetron oral disintegrating tablets. Sandoz Canada Inc. (per Health Canada), Boucherville, QC, Canada, 2015.