Amitriptyline Hydrochloride 10 Mg

Amitryptilline tablets should be swallowed whole with water. Amitryptilline can be administered with or without food.

Store at controlled room temperature 20 to 25 degrees C . in a well-closed container protect from light

Common Endocrine metabolic: Weight gain Gastrointestinal: Constipation, Xerostomia Neurologic: Dizziness, Extrapyramidal movements, Headache, Somnolence Ophthalmic: Blurred vision

Amitriptyline hydrochloride is contraindicated in patients who have shown prior hypersensitivity to it. It should not be given concomitantly with monoamine oxidase inhibitors. Hyperpyretic crises severe convulsions and deaths have occurred in patients receiving tricyclic antidepressant and monoamine oxidase inhibiting drugs simultaneously. When it is desired to replace a monoamine oxidase inhibitor with amitriptyline hydrochloride a minimum of 14 days should be allowed to elapse after the former is discontinued. Amitriptyline hydrochloride should then be initiated cautiously with gradual increase in dosage until optimum response is achieved. Amitriptyline hydrochloride should not be given with cisapride due to the potential for increased QT interval and increased risk for arrhythmia. This drug is not recommended for use during the acute recovery phase following myocardial infarction."

Discontinue the medication and seek medical attention if any signs of allergic reactions or severe side effects occur such as skin rash, swelling, difficulty breathing, or suicidal thoughts. Use with caution in patients with a history of cardiovascular disease, seizures, urinary retention, or glaucoma. Avoid alcohol consumption while taking Amitriptyline as it may enhance sedative effects and increase the risk of adverse reactions.

Ayd, F.J., Jr.: Amitriptyline therapy for depressive reactions Psychosom. 1: 320-325, Nov.-Dec. 1960 Diamond, S.: Human metabolization of amitriptyline tagged with carbon 14, Curr. Therap. Res. 7: 170-175, Mar. https://aapharma.ca/downloads/en/PIL/2021/Elavil_PM_EN.pdf 1965.https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1e6d2c80-fbc8-444e-bdd3-6a91fe1b95bd## "

Amitriptyline HCl is an antidepressant with sedative effects. Its mechanism of action in man is not known. It is not a monoamine oxidase inhibitor and it does not act primarily by stimulation of the central nervous system. Amitriptyline inhibits the membrane pump mechanism responsible for uptake of norepinephrine and serotonin in adrenergic and serotonergic neurons. Pharmacologically, this action may potentiate or prolong neuronal activity since reuptake of these biogenic amines is important physiologically in terminating transmitting activity. This interference with reuptake of norepinephrine and/or serotonin is believed by some to underlie the antidepressant activity of amitriptyline.

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