Product Details
ATORVASTATIN 80 MG
Introduction : Atorvastatin 80mg tablet is used together with a proper diet to lower cholesterol and triglyceride (fats) levels in the blood. This medicine may help prevent medical problems (eg, chest pain, heart attack, or stroke) that are caused by fats clogging the blood vessels. It may also be used to prevent certain types of heart and blood vessel problems in patients with risk factors for heart problems.
Atorvastatin 80mg tablet belongs to the group of medicines called HMG-CoA reductase inhibitors, or statins. It works by blocking an enzyme that is needed by the body to make cholesterol, and this reduces the amount of cholesterol in the blood.
This medicine is available only with your doctors prescription.
Indication : Atorvastatin 80mg tablet is indicated to reduce the risk of:
Myocardial infarction (MI), stroke, revascularization procedures, and angina in adults with multiple risk factors for coronary heart disease (CHD) but without clinically evident CHD.
Administration : Take it at the same time each day.
Swallow the tablet whole. Do not break, crush, or chew it. Take this medicine with or without food.
Do not drink large amounts of alcohol with atorvastatin. This could cause unwanted effects on the liver.
Storage : Store at a controlled room temperature between 20 and 25 degrees C
Mechanism of Action : Atorvastatin calcium selectively and competitively inhibits HMG-CoA reductase, a rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate, a sterol and cholesterol precursor, Triglycerides and cholesterol are incorporated into very low density lipoproteins (VLDL) in the liver and are released into plasma for distribution to peripheral tissues. Low-density lipoproteins (LDL) are formed from VLDL and are catabolized primarily through the receptor with high affinity for LDL receptor. Atorvastatin reduces plasma cholesterol and lipoprotein concentrations by inhibiting HMG-CoA reductase and subsequent hepatic cholesterol biosynthesis in the liver and increasing the number of liver receptors for LDL on the cell surface, leading to increased absorption and catabolism of LDL. Atorvastatin reduces LDL production and produces a profound and sustained increase in LDL receptor activity along with a beneficial change in the quality of circulating LDL
Therapeutic : Antihyperlipidemic
Side Effects : nasopharyngitis, arthralgia, diarrhea, pain in extremity, and urinary tract
infection
Side effects may include diarrhea, UTIs, extremity pain, nasopharyngitis, and arthralgia
Contraindications : Active liver disease, which may include unexplained persistent elevations
in hepatic transaminase levels
? Hypersensitivity to any component of this medication (4).
? Pregnancy .
? Lactation
Safety Advice / Warnings : Do not drink large amounts of alcohol with atorvastatin. This could cause unwanted effects on the liver.
It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly to lower your cholesterol and triglyceride levels and to decide if you should continue to take it. Blood tests may be needed to check for unwanted effects.
Call your doctor right away if you have dark-colored urine, fever, muscle cramps or spasms, muscle pain or stiffness, or unusual tiredness or weakness. These could be symptoms of a serious muscle problem called rhabdomyolysis, which can cause kidney problems.
Using this medicine while you are pregnant can harm your unborn baby.
References : Product Information: LIPITOR(R) oral tablets, atorvastatin calcium oral tablets. Parke-Davis (Per FDA), New York, NY, 2014
Product Information: Atorvastatin Uxa oral tablet, atorvastatin calcium trihydrate oral tablet. Uxa Farma SA (per AEMPS;Spain), Avda. San Francisco Javier 24, 41018 Seville, Spain, 2019.