Amitriptyline Hydrochloride 25 Mg

Amitriptyiline hydorchroide 25mg is INDICATED For the relief of symptoms of depression. Endogenous depression is more likely to be alleviated than are other depressive states.

Amitryptilline tablets should be swallowed whole with water. Amitryptilline can be administered with or without food.

Store at controlled room temperature, 20 to 25 degrees C (68 to 77 degrees F) in a well-closed container protect from light.

Common Endocrine metabolic: Weight gain Gastrointestinal: Constipation, Xerostomia Neurologic: Dizziness, Extrapyramidal movements, Headache, Somnolenc Ophthalmic: Blurred vision Serious Cardiovascular: Atrioventricular conduction disorder, Cardiac dysrhythmia, Electrocardiogram abnormal, Heart block, Myocardial infarction, Prolonged QT interval, Sudden cardiac death Hematologic: Bone marrow depression Hepatic: Cholestasis, Hepatitis Neurologic: Cerebrovascular accident, Coma, Seizure Psychiatric: Depression, Worsening, Hypomania, Mania, Suicidal thoughts .

Amitriptyline hydrochloride is contraindicated in patients who have shown prior hypersensitivity to it.

It should not be given concomitantly with monoamine oxidase inhibitors. Hyperpyretic crises, severe convulsions, and deaths have occurred in patients receiving tricyclic antidepressant and monoamine oxidase inhibiting drugs simultaneously. Amitriptyline hydrochloride should then be initiated cautiously with gradual increase in dosage until optimum response is achieved. This drug is not recommended for use during the acute recovery phase following myocardial infarction.

Ayd, F.J., Jr.: Amitriptyline therapy for depressive reactions, Psychosom. 1: 320-325, Nov.-Dec. 1960. Diamond, S.: Human metabolization of amitriptyline tagged with carbon 14, Curr. Therap. Res. 7: 170-175, Mar. https://aapharma.ca/downloads/en/PIL/2021/Elavil_PM_EN.pdf 1965.https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1e6d2c80-fbc8-444e-bdd3-6a91fe1b95bd##

Amitriptyline HCl is an antidepressant with sedative effects. Its mechanism of action in man is not known. It is not a monoamine oxidase inhibitor and it does not act primarily by stimulation of the central nervous system. Amitriptyline inhibits the membrane pump mechanism responsible for uptake of norepinephrine and serotonin in adrenergic and serotonergic neurons, Pharmacologically this action may potentiate or prolong neuronal activity since reuptake of these biogenic amines is important physiologically in terminating transmitting activity. This interference with reuptake of norepinephrine and or serotonin is believed by some to underlie the antidepressant activity of amitriptyline.

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