STRIP of 10 TAB.

Rx Prescription Required


Manufacturer : LIFE MAX CANCERIn StockProduct Code : GMP0010MRP : ₹ 23.00 (Inclusive of all taxes)₹ 22.004.35% Off Quantity : This Product is not for Online Sale, You can purchase it from Physical Store.

Product Details


Introduction :

Amitriptyiline hydorchroide 25mg is a Drug which is used tfor management of depressive illness. ? Depressive illness of psychotic or endogenous nature and in selected patients with neurotic depression. Endogenous depression is more likely to be alleviated than are other depressive states. Amitryptilline, because of its sedative action, is also of value in alleviating the anxiety component of depression. "

Indication :

Amitriptyiline hydorchroide 25mg is INDICATED For the relief of symptoms of depression. Endogenous depression is more likely to be alleviated than are other depressive states.

Administration :

Amitryptilline tablets should be swallowed whole with water. Amitryptilline can be administered with or without food.

Storage :

Store at controlled room temperature, 20 to 25 degrees C (68 to 77 degrees F), in a well-closed container; protect from light

Mechanism of Action :

Amitriptyline HCl is an antidepressant with sedative effects. Its mechanism of action in man is not known. It is not a monoamine oxidase inhibitor and it does not act primarily by stimulation of the central nervous system. Amitriptyline inhibits the membrane pump mechanism responsible for uptake of norepinephrine and serotonin in adrenergic and serotonergic neurons. Pharmacologically, this action may potentiate or prolong neuronal activity since reuptake of these biogenic amines is important physiologically in terminating transmitting activity. This interference with reuptake of norepinephrine and/or serotonin is believed by some to underlie the antidepressant activity of amitriptyline.

Therapeutic :

Anti depressant

Side Effects :

Common Endocrine metabolic: Weight gain Gastrointestinal: Constipation, Xerostomia Neurologic: Dizziness, Extrapyramidal movements, Headache, Somnolence Ophthalmic: Blurred vision Serious Cardiovascular: Atrioventricular conduction disorder, Cardiac dysrhythmia, Electrocardiogram abnormal, Heart block, Myocardial infarction, Prolonged QT interval, Sudden cardiac death Hematologic: Bone marrow depression Hepatic: Cholestasis, Hepatitis Neurologic: Cerebrovascular accident, Coma, Seizure Psychiatric: Depression, Worsening, Hypomania, Mania, Suicidal thoughts

Contraindications :

Amitriptyline hydrochloride is contraindicated in patients who have shown prior hypersensitivity to it.

Safety Advice / Warnings :

It should not be given concomitantly with monoamine oxidase inhibitors. Hyperpyretic crises, severe convulsions, and deaths have occurred in patients receiving tricyclic antidepressant and monoamine oxidase inhibiting drugs simultaneously. Amitriptyline hydrochloride should then be initiated cautiously with gradual increase in dosage until optimum response is achieved. This drug is not recommended for use during the acute recovery phase following myocardial infarction.

References :

Ayd, F.J., Jr.: Amitriptyline therapy for depressive reactions, Psychosom. 1: 320-325, Nov.-Dec. 1960. Diamond, S.: Human metabolization of amitriptyline tagged with carbon 14, Curr. Therap. Res. 7: 170-175, Mar. 1965.


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