Product Details
PREGABALIN 75 MG ( SR ) + METHYLCOBALAMIN 1500 MCG
Introduction : Pregabalin 75 Mg SR (Sustained Release) + Methylcobalamin 1500 Mcg capsule is used to treat long-lasting (chronic) pain caused by nerve damage due to diabetes, shingles or spinal cord injury. It reduces pain and its associated symptoms such as mood changes, sleep problems, and tiredness.
Pregabalin, an active ingredient of this medicine, is thought to work by interfering with pain signals that travel through the damaged nerves and the brain.
Methylcobalamin, a form of vitamin B12, supports nerve function and regeneration, which can help alleviate neuropathic pain symptoms.
Indication : Pregabalin 75 Mg SR (sustained release) + Methylcobalamin 1500 Mcg capsule is primarily used for the management of neuropathic pain. Neuropathic pain arises from damage or dysfunction of the nervous system and can be chronic.
The combination of Pregabalin 75 Mg SR (Sustained Release) + Methylcobalamin 1500 Mcg capsule is also used in the treatment of peripheral neuropathy, a common complication of conditions such as diabetes mellitus and vitamin B12 deficiency.
Administration : Administer orally with or without food, as directed by the healthcare provider.
Storage : Store the medicine at room temperature, away from heat, moisture, and direct light.
Mechanism of Action : Pregabalin: It is an anticonvulsant and analgesic medication that binds to calcium channels in the central nervous system, reducing the release of neurotransmitters involved in pain signaling. Pregabalin is effective in treating neuropathic pain associated with conditions such as diabetic neuropathy, postherpetic neuralgia, and fibromyalgia.
Methylcobalamin: It is a form of vitamin B12 that plays a crucial role in nerve function and regeneration. Methylcobalamin helps maintain the health of nerve cells and is used in the treatment of peripheral neuropathy, a common complication of conditions such as diabetes and vitamin B12 deficiency.
Therapeutic : analgesics and neurological agents.
Side Effects : Dizziness, Drowsiness, Headache, Fatigue
Nausea, Dry mouth, Weight gain, Edema (swelling)
Blurred vision
Constipation, Difficulty concentrating
Contraindications : Consult a healthcare professional before using this medication if you are pregnant, breastfeeding,
Safety Advice / Warnings : Use caution when driving or operating machinery, as this medication may cause dizziness or drowsiness.
"The use of alcohol or other medicines that affect the CNS with pregabalin may worsen the side effects of this medicine, such as dizziness, poor concentration, drowsiness, unusual dreams, and trouble with sleeping
This medicine may cause respiratory depression, a serious breathing problem that can be life-threatening, when used together with narcotic pain medicines. Check with your doctor right away
Pregabalin may cause blurred vision, double vision, clumsiness, unsteadiness, dizziness, drowsiness, or trouble with thinking. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. If these side effects are especially bothersome, check with your doctor.
Do not suddenly stop taking pregabalin without checking first with your doctor.
patient to avoid drinking alcohol
Extended-release tablets: If a dose is missed with the evening meal, instruct patient to take before bedtime after a snack or the following morning after a meal. "
References : Mishra S, Bhatnagar S, Goyal GN, et al. A Comparative Efficacy of Amitriptyline, Gabapentin, and Pregabalin in Neuropathic Cancer Pain: A Prospective Randomized Double-Blind Placebo-Controlled Study. Am J Hosp Palliat Care. 2012
Product Information: LYRICA(R) oral capsules, pregabalin oral capsules. Pfizer,Inc, New York, NY, 2007.
Feltner DE, Crockatt JG, Dubovsky SJ, et al: A randomized, double-blind, placebo-controlled, fixed-dose, multicenter study of pregabalin in patients with generalized anxiety disorder. J Clin Psychopharmacol 2003; 23(3):240-249."
Yoshioka K & Tanaka K: Effect of methylcobalamin on diabetic neuropathy as assessed by power spectral analysis of heart rate variations. Horm Metab Res 1995; 27(1):43-44.