Product Details
CLOPIDOGREL 75 MG
Introduction : Clopidogrel 75mg tablet is used alone or together with other medicines to lessen the chance of a heart attack or stroke.
It is given to patients with acute coronary syndrome (ACS), to patients who have already had a heart attack, severe chest pain, or a stroke, or to patients with other circulation problems (eg, peripheral arterial disease) that could cause a stroke or heart attack. Acute coronary syndrome is a condition where the blood flow to the heart is blocked.
A heart attack or stroke may occur when a blood vessel is blocked by a blood clot.
Clopidogrel 75mg Tablet reduces the chance that a harmful blood clot will form by preventing platelets from clumping together in the blood. Clopidogrel 75mg tablet may also increase the chance of serious bleeding in some people.
This medicine is available only with your doctors prescription.
Indication : Clopidogrel 75mg tablet is used to prevent heart attacks and strokes in persons with heart disease (recent heart attack), recent stroke, or blood circulation disease (peripheral vascular disease).
It is also used with aspirin to treat new/worsening chest pain (new heart attack, unstable angina) and to keep blood vessels open and prevent blood clots after certain procedures (such as cardiac stent).
Clopidogrel 75mg tablet works by blocking platelets from sticking together and prevents them from forming harmful clots. It is an antiplatelet drug. It helps keep blood flowing smoothly in your body.
Administration : You may take this medicine with or without food.
If you are also taking omeprazole ) or esomeprazole , do not use it at the same time that you take this medicine. Talk with your doctor about using a different antacid.
Your doctor may tell you to take aspirin while you are using clopidogrel. Do not change the dose or stop taking the aspirin without talking to your doctor first.
Storage : Store in a cool and dry place away from sunlight
Mechanism of Action : Clopidogrel bisulfate is a thienopyridine class inhibitor of CYP2Y12 adenosine diphosphate (ADP) platelet receptors. Clopidogrel must be metabolized by CYP450 enzymes to produce its active metabolite. The active metabolite selectively and irreversibly inhibits the binding of ADP to its platelet P2Y12 receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. Consequently, platelets exposed to the active metabolite are affected for the remainder of their lifespan (about 7 to 10 days). Platelet aggregation induced by agonists other than ADP is also inhibited by blocking the amplification of platelet activation by released ADP
Therapeutic : Platelet Aggregation Inhibitor
Side Effects : Side effects may include rash, pruritus, colitis, diarrhea, hepatotoxicity, itching, pain, redness, or swelling
Contraindications : Active pathological bleeding, including peptic ulcer or intracranial hemorrhage
Hypersensitivity (eg, anaphylaxis) to clopidogrel or any component of the product
Safety Advice / Warnings : While you are using this medicine, if you have any kind of bleeding, it may take longer than usual to stop, especially if you hurt yourself. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Be careful when using sharp objects, including razors and fingernail clippers.
Avoid use of this drug during pregnancy and prescribe an alternative. Evidence has demonstrated fetal abnormalities or risks when used during pregnancy.
Evidence and/or expert consensus has demonstrated harmful infant effects when used during breastfeeding.
Avoid eating grapefruit or drinking grapefruit juice while using this medication
If you are also taking omeprazole ) or esomeprazole , do not use it at the same time that you take this medicine. Talk with your doctor about using a different antacid.
References : Product Information: PLAVIX(R) oral tablets, clopidogrel bisulfate oral tablets. Bristol-Myers Squibb/Sanofi Pharmaceuticals Partnership (per FDA), Bridgewater, NJ, 2021.
Product Information: Zyllt oral tablet, clopidogrel oral tablet. KRKA, DD, Novo Mesto (per AEMPS;Spain), 2019.
Product Information: Cupido oral tablet, clopidogrel oral tablet. Apotex (per SFDA; Saudi Arabia), 2019.