Product Details
FRUSEMIDE 20 MG + SPIRONOLACTONE 50 MG
Introduction : Frusemide 20 Mg + Spironolactone 50 Mg tablet is indicated for :
Management of Congestive Heart Failure: Frusemide and Spironolactone combination is often used in the management of congestive heart failure (CHF), a condition characterized by the hearts inability to pump blood effectively, leading to fluid buildup in the body. Frusemide, a loop diuretic, helps to remove excess fluid from the body by increasing urine production, thereby reducing fluid retention and relieving symptoms of congestion. Spironolactone, a potassium-sparing diuretic, works by blocking the actions of aldosterone, a hormone that regulates sodium and water balance, thereby promoting diuresis and reducing potassium loss
Frusemide and Spironolactone combination may also be used in the management of hypertension (high blood pressure) in certain cases, particularly in patients with fluid retention or resistant hypertension.
Indication : Frusemide 20 Mg + Spironolactone 50 Mg is a medicine used in the treatment of congestive heart failure, nephrotic syndrome, ascites associated with liver cirrhosis, and mild and moderate degrees of essential hypertension. It works by reducing the excess fluid levels in the body while maintaining the potassium balance.
Administration : Administer orally with a full glass of water, as directed by the healthcare provider.
The tablet can be taken with or without food.
It is essential to take the medication at the same time(s) each day to maintain consistent drug levels in the body.
Storage : Store the medicine at room temperature, away from heat, moisture, and direct light.
Keep out of the reach of children"
Side Effects : Electrolyte imbalances (e.g., hypokalemia, hyponatremia)
Dehydration
Dizziness
Headache
Muscle cramps
Nausea
Diarrhea
Increased urination
Hypotension
Contraindications : If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this
medicine.
You must not take this medicine while you are breast-feeding and during pregnancy
Safety Advice / Warnings : Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have the following symptoms: stomach pain, confusion, difficulty with breathing, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet, or lips, or weakness or heaviness of the legs
Spironolactone may worsen kidney function in patients with low to no salt in their body or in those who take other blood pressure medicines
This medicine may also cause electrolyte imbalances (including low sodium, magnesium, and calcium in the blood, hypochloremic alkalosis) and an increase in your uric acid and blood sugar levels.
Avoid concurrent use of potassium supplements or potassium-containing salt substitutes, as it may increase the risk of hyperkalemia.
Advise patient to use sunscreen, wear protective clothing, and avoid tanning beds as drug may cause photosensitivity
References : Product Information: Aldactone(R) oral tablets, spironolactone oral tablets. G.D. Searle (per FDA), New York, NY, 2014.
Product Information: Aldactone(R), spironolactone tablets, USP. Pharmacia Corp., Chicago, IL, 2003.
Product Information: LASIX(R) oral tablets, furosemide oral tablets. sanofi-aventis U.S. LLC, Bridgewater, NJ, 2010.
Beermann B & Groschinsky-Grind MG: Clinical pharmacokinetics of diuretics. Clin Pharmacokinet 1980; 5:221-245
Mechanism of Action : Frusemide: It is a loop diuretic that works by inhibiting the reabsorption of sodium and chloride in the ascending loop of Henle in the kidneys, leading to increased urine production and excretion of water, sodium, chloride, and other electrolytes.
Spironolactone: It is a potassium-sparing diuretic that works by antagonizing the effects of aldosterone, a hormone that promotes sodium reabsorption and potassium excretion in the distal tubules of the kidneys. Spironolactone promotes diuresis while conserving potassium, thereby preventing hypokalemia.
Therapeutic : Diuretucs / Anti Hypertensive