Nitroglycerin 2.6(cr)

Swallow the extended-release capsule whole. Do not split, crush, or chew it. You should take the Controlled-release capsule first thing in the morning and follow the same schedule each day. This medicine works best if you have a ""drug-free"" period of time every day when you do not take it. Your doctor will schedule your doses during the day to allow for a drug-free time. Follow the schedule of dosing carefully so the medicine will work properly. Store the controlled-release capsules in a closed container at room temperature, away from heat, moisture, and direct light.

Protect from moisture or light and store below 30 degrees Celsius (C).

Hypotension Flushing, Dizziness, Headache, Lightheadedness, skin reactions.

Avoid use of this drug during pregnancy and prescribe an alternative. Evidence has demonstrated fetal abnormalities or risks when used during pregnancy. Evidence and/or expert consensus has demonstrated harmful infant effects when used during breastfeeding.

Blurred vision or dryness of the mouth may occur while using this medicine. Check with your doctor if this concerns you. This medicine may cause headaches. These headaches are a sign that the medicine is working. Do not stop using the medicine or change the time you use it in order to avoid the headaches. If you have severe pain, talk with your doctor. Dizziness, lightheadedness, or fainting may occur, especially when you get up quickly from a lying or sitting position. Getting up slowly may help. Also, lying down for a while may relieve dizziness or lightheadedness. Do not stop using this medicine without checking first with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely.

Product Information: nitroglycerin oral extended-release capsule, nitroglycerin oral extended-release capsule. Ethex Corporation, St. Louis, MO, 1998. Product Information: NITROQUICK(R) sublingual tablet, nitroglycerin sublingual tablet. Ethex Corporation, St. Louis, MO, 2002.

Nitroglycerin, an organic nitrate, is a vasodilating agent that relieves tension on vascular smooth muscle and dilates peripheral veins and arteries. It increases guanosine 3'5' monophosphate (cyclic GMP) in smooth muscle and other tissues by stimulating guanylate cyclase through formation of free radical nitric oxide. This activity results in dephosphorylation of the light chain of myosin, which improves the contractile state in smooth muscle results in vasodilation.

Antianginal