Product Details
OLMESARTAN MEDOXOMIL 20 MG + CHLORTHALIDONE 12.50 MG
Introduction : Olmesartan medoxomil 20mg & Chlorthalidone 12.5mg combination tablets are indicated for the treatment of hypertension in adults who require combination therapy to achieve blood pressure control.
Chlorthalidone is also used to reduce extra salt and water in the body. Decreasing extra salt and water in the body helps to decrease swelling (edema) and breathing problems caused by fluid in the lungs. Chlorthalidone is a "water pill" (diuretic). It increases the amount of urine you make, especially when you first start the medication. It also helps to relax the blood vessels so that blood can flow more easily.
Olmesartan works by blocking a substance in the body that causes the blood vessels to tighten. As a result, olmesartan relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.
Indication : Olmesartan medoxomil 20mg & Chlorthalidone 12.5mg combination tablets is primarily prescribed for the treatment of hypertension (high blood pressure) in adults. It is particularly beneficial for individuals whose blood pressure is not adequately controlled with monotherapy or who require combination therapy to achieve target blood pressure levels.
By lowering blood pressure, this medication helps reduce the risk of cardiovascular events such as heart attacks, strokes, and other complications associated with hypertension.
Administration : This medicine may be taken with or without food.
In addition to taking this medicine, treatment for your high blood pressure may include weight control and a change in the foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you.
Storage : Protect from moisture or light and store below 30 degrees Celsius (C))
Mechanism of Action : Olmesartan medoxomil is an angiotensin II receptor blocker (ARB) that works by blocking the action of angiotensin II, a substance in the body that causes blood vessels to tighten, thereby relaxing blood vessels and lowering blood pressure.
Chlorthalidone is a thiazide diuretic that works by increasing the excretion of sodium and water from the body, leading to reduced blood volume and decreased blood pressure.
Therapeutic : Cardiovascular Agent
Side Effects : dizziness, headache, hypotension (low blood pressure), electrolyte imbalances (such as low potassium levels), increased uric acid levels, and increased blood glucose levels.
Contraindications : "Evidence has demonstrated fetal abnormalities or risks when used during pregnancy and breast feeding. consult with doctor immidaitely
Safety Advice / Warnings : "Before taking chlorthalidone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely.
Severe, chronic diarrhea with weight loss may develop months to years after taking this medicine. Tell your doctor right away if you have these symptoms.
Do report symptoms of potassium loss
Side effects may include hypotension, dizziness, and renal dysfunction
Do not drink alcohol while taking this drug, as this may aggravate hypotension."
References : Beermann B & Groschinsky-Grind MG: Clinical pharmacokinetics of diuretics. Clin Pharmacokinet 1980; 5:221-245.
Product Information: Chlorthalidone oral tablets, chlorthalidone oral tablets. Sun Pharmaceutical Industries Inc (per DailyMed), Cranbury, NJ, 2017.
Product Information: BENICAR(R) oral tablets, olmesartan medoxomil oral tablets. Daiichi Sankyo, Inc. (per FDA), Parsippany, NJ, 2013.
Barrios V, Boccanelli A, Ewald S, et al: Efficacy and tolerability of olmesartan medoxomil in patients with mild to moderate essential hypertension: the OLMEBEST Study. Clin Drug Investig 2007; 27(8):545-558.