Product Details
RAMIPRIL 5 MG + HYDROCHLOROTHIAZIDE 12.5 MG
Introduction : This combination of Ramipril 5 Mg +Hydrochlorothiazide 12.5 Mg tablet is indicated for the treatment of hypertension (high blood pressure) in patients whose blood pressure is not adequately controlled with monotherapy (single-drug therapy).
It may also be prescribed to reduce the risk of cardiovascular events in hypertensive patients.
Hydrochlorothiazide belongs to a class of drugs known as diuretics/"water pills." It works by causing you to make more urine. This helps your body get rid of extra salt and water.This medication also reduces extra fluid in the body (edema) caused by conditions such as heart failure, liver disease, or kidney disease. This can lessen symptoms such as shortness of breath or swelling in your ankles or feet.
Ramipril is an angiotensin-converting enzyme (ACE) inhibitor. It works by blocking a substance in the body that causes blood vessels to tighten. As a result, ramipril relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.
Indication : Ramipril 5 Mg +Hydrochlorothiazide 12.5 Mg tablet is used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This product contains 2 medications: tRamipril and hydrochlorothiazide. Telmisartan belongs to a class of drugs called angiotensin receptor blockers (ARBs).
It works by relaxing blood vessels so blood can flow more easily. Hydrochlorothiazide is a "water pill" (diuretic). It increases the amount of urine you make, especially when you first start the medication. It also helps to relax the blood vessels so that blood can flow more easily.These medications are used together when 1 drug alone is not controlling your blood pressure.
Administration : Typically, one tablet is taken orally once daily, with or without food.
Its essential to follow the dosage instructions provided by your healthcare provider and not to exceed the prescribed dose.
It is best to avoid taking this medication within 4 hours of your bedtime to avoid having to get up to urinate.
Storage : Store the medication at room temperature, away from moisture and heat.
Keep it out of reach of children
Mechanism of Action : Ramipril, an angiotensin-converting enzyme (ACE) inhibitor, is metabolized to a more potent ramiprilat (active drug). Both prevent the conversion of angiotensin I to angiotensin II, a vasoconstrictor agent, which decreases vasopressor activity and aldosterone secretion
Hydrochlorothiazide increases urine production by inhibiting the reabsorption of sodium and chloride ions in the kidneys, resulting in the removal of excess salt and water from the body and lowering blood volume and pressure.
Therapeutic : Cardiovascular Agent
Side Effects : Common side effects may include dizziness, headache, fatigue, electrolyte disturbances (such as low potassium levels), increased urination, and dehydration.
Contraindications : Evidence and/or expert consensus has demonstrated harmful infant effects when used during breastfeeding.
Avoid use of this drug during pregnancy and prescribe an alternative. Evidence has demonstrated fetal abnormalities or risks when used during pregnancy.
Safety Advice / Warnings : This medication may cause dizziness or lightheadedness, especially during the first few days of treatment or when standing up quickly from a sitting or lying position. Use caution when driving or operating machinery until you know how the medication affects you.
Avoid consuming alcohol while taking this medication, as it may potentiate the blood pressure-lowering effects and increase the risk of side effects.
Inform your healthcare provider about any other medications, supplements, or medical conditions you have before starting treatment with telmisartan/hydrochlorothiazide.
Patient should avoid activities requiring mental alertness or coordination until drug effects are realized, as drug may cause dizziness.
Advise patient to rise slowly from a sitting or lying position.
Patient should avoid using potassium-containing supplements or salts while taking this drug.
References : Product Information: ALTACE(R) oral capsules, ramipril oral capsules. King Pharmaceuticals, Inc, Bristol, TN, 2010.
Heintz B, Verho M, Brockmeier D, et al: Multiple-dose pharmacokinetics of ramipril in patients with chronic congestive heart failure. J Cardiovasc Pharmacol 1993; 22(suppl 9):S36-S42.
"Product Information: Hydrochlorothiazide Aurovitas oral tablet, hydrochlorothiazide oral tablet. Aurovitas Spain, SAU (per AEMPS;Spain), Avda, De Burgos, 28036 Madrid, Spain, 2019.
Product Information: Hydrochlorothiazide oral tablets, hydrochlorothiazide oral tablets. Accord Healthcare Inc (per DailyMed), Durham, NC, 2020.