Product Details
TELMISARTAN 40 MG + AMLODIPINE 5 MG
Introduction : This combination of Telmisartan 40mg and Amlodipine 5mg tablet work together to lower blood pressure by dilating blood vessels and improving blood flow, thus reducing strain on the heart.
Amlodipine is used to treat high blood pressure (hypertension) and a type of chest pain called angina. High Blood Pressure (hypertension) High blood pressure comes from blood pushing too hard against your blood vessels.
Telmisartan is an angiotensin II receptor blocker (ARB). It works by blocking a substance in the body that causes blood vessels to tighten. As a result, telmisartan relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.
Indication : Telmisartan 40mg and Amlodipine 5mg tablet is used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This product contains 2 medication Telmisartan is an angiotensin receptor blocker (ARB) and amlodipine is a calcium channel blocker.
Telmisartan 40mg and Amlodipine 5mg tablet work differently to relax the blood vessels so that blood can flow more easily.These medications are used together when one drug is not controlling your blood pressure.
Administration : May be administered with or without food
Tablets should not be removed from blisters until immediately before administration
Storage : Keep away from children. Store amlodipine Tablets
at room temperature under 30 degree celcius. Keep
out of the light. Do not store in the bathroom. Keep
in a dry place.
Side Effects : Dizziness or lightheadedness may occur as your body adjusts to the medication. Swelling hands/ankles/feet or flushing may also occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
Contraindications : This drug can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy. It is important to prevent pregnancy while taking this medication.
Safety Advice / Warnings : This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
Severe sweating, diarrhea, or vomiting may cause dehydration and cause you to feel lightheaded. Tell your doctor if you have severe diarrhea or vomiting. To prevent dehydration, drink plenty of fluids unless your doctor tells you not to.
Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away.
References : "Norvasc (amlodipine besylate) tablets label ;
Amlodipine besylate [FDA Label]. New York, NY: Pfizer Labs.; 1987 [revised May 2011]. [Accessed 14 Mar. 2019] (online) Available from:External Link"
"Product Information: MICARDIS(R) oral tablets, telmisartan oral tablets. Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT, 2009
Product Information: Telmisartan. Boehringer Ingelheim, US, 98.
Mechanism of Action : Systemic: Telmisartan is a nonpeptide angiotensin II antagonist that selectively blocks the binding of angiotensin II to the AT 1 receptors in vascular smooth muscle and the adrenal gland. In the renin-angiotensin system, angiotensin I is converted by angiotensin-converting enzyme (ACE) to form angiotensin II . Angiotensin II stimulates the adrenal cortex to synthesize and secrete aldosterone, which decreases the excretion of sodium and increases the excretion of potassium
Amlodipine is a dihydropyridine calcium channel blocker that exerts its effect by blocking the transmembrane influx of calcium ions into cardiac and vascular smooth muscles. It also reduces peripheral vascular resistance and lowers blood pressure by acting directly on vascular smooth muscle. Its therapeutic effect on angina may be through a decrease in peripheral resistance (exertional angina) and inhibition of coronary spasm (vasospastic angina)
Therapeutic : Cardiovascular Agent