Product Details
TELMISARTAN 40 MG + METOPROLOL TARTRATE 25 MG
Introduction : The combination of Telmisartan 40mg + Metoprolol Tartrate 25mg tablet is primarily used for the management of hypertension (high blood pressure) in adults. It helps to control blood pressure by blocking the effects of angiotensin II and adrenaline, thereby reducing the workload on the heart and relaxing blood vessels.
Indication : The combination of Telmisartan 40mg + Metoprolol 25mg tablet is commonly indicated for the treatment of hypertension (high blood pressure) in adults.
Telmisartan is also used to lower the risk of heart attacks or stroke in patients 55 years of age and older who have diabetes or heart problems.
Metoprolol is also used to treat severe chest pain (angina) and lowers the risk of repeated heart attacks. It is given to people who have already had a heart attack. In addition, metoprolol is used to treat patients with heart failure.
Administration : It is typically taken orally once daily with food
Swallow the tablet or extended-release tablet whole with a full glass of water. Do not crush, break, or chew it.
Storage : Store the medication at room temperature, away from moisture and heat.
Keep it out of reach of children
Side Effects : Dizziness
Fatigue
Headache
Hypotension (low blood pressure)
Bradycardia (slow heart rate)
Gastrointestinal disturbances
Cold extremities
Shortness of breath
Insomnia
Contraindications : Evidence and/or expert consensus has demonstrated harmful infant effects when used during breastfeeding.
Avoid use of this drug during pregnancy and prescribe an alternative. Evidence has demonstrated fetal abnormalities or risks when used during pregnancy.
Safety Advice / Warnings : This medication combination should be used with caution in patients with impaired liver or kidney function.
Patients should be monitored regularly for signs of hypotension, especially when initiating therapy or adjusting the dosage.
Abrupt discontinuation of beta-blockers like metoprolol may exacerbate angina or precipitate myocardial infarction, so dosage should be gradually tapered if discontinuation is necessary.
Metoprolol may cause changes in blood sugar levels. Also, this medicine may cover up the symptoms of low blood sugar (including fast heartbeat) and increase the risk for serious or prolonged hypoglycemia (low blood sugar). Check with your doctor if you notice a change in your normal symptoms.
Dizziness, lightheadedness, or even fainting may occur when you get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem. Also, lying down for a while may relieve the dizziness or lightheadedness.
References : Product Information: Telmisartan. Boehringer Ingelheim, US, 98.
Weber MA, Schiffrin EL, White WB, et al. Clinical practice guidelines for the management of hypertension in the community: a statement by the American Society of Hypertension and the International Society of Hypertension. J Hypertens. 2014
Product Information: Lopressor(R) oral tablets, metoprolol tartrate oral tablets. Validus Pharmaceuticals, LLC (per FDA), Parsippany, NJ, 2013.
Mechanism of Action : Telmisartan 40 mg: Telmisartan is an angiotensin II receptor blocker (ARB) that helps relax blood vessels to lower blood pressure. It works by blocking the action of angiotensin II, a hormone that narrows blood vessels, thereby reducing blood pressure.
Metoprolol Tartrate 25 mg: Metoprolol is a beta-blocker that blocks the effects of adrenaline on the heart and blood vessels. It slows down the heart rate, reduces the force of contraction of the heart muscle, and lowers blood pressure.
Therapeutic : Cardiovascular Agent