Product Details
GLICLAZIDE 40 MG + METFORMIN HYDROCLORIDE 500 MG
Introduction : Gliclazide 40 Mg + Metformin Hydrocloride 500 Mg medication is indicated for the treatment of type 2 diabetes mellitus in adults, particularly when blood sugar levels are not adequately controlled by diet and exercise alone. It helps to lower blood sugar levels by addressing different aspects of glucose metabolism:
Gliclazide stimulates insulin release from the pancreas, thereby reducing blood sugar levels.
Metformin decreases glucose production in the liver, improves insulin sensitivity in peripheral tissues, and reduces intestinal glucose absorption.
Indication : Gliclazide 40 Mg + Metformin Hydrocloride 500 Mg tablet is primarily prescribed for the management of type 2 diabetes mellitus. It helps control blood sugar levels by addressing multiple aspects of glucose metabolism.
Gliclazide 40 mg + Metformin Hydrochloride 500 mg combination medication is also used to reduce the risk of long-term complications associated with diabetes, such as cardiovascular disease, neuropathy, nephropathy, and retinopathy. By maintaining stable blood sugar levels and improving insulin sensitivity, this medication helps mitigate the adverse effects of hyperglycemia on various organs and tissues in the body.
Administration : The dosage of Gliclazide 40 mg + Metformin Hydrochloride 500 mg may vary depending on the patients blood sugar levels
It is typically taken orally, usually once or twice daily with meals to reduce the risk of gastrointestinal side effects.
Storage : Keep this medicine out of the sight and reach of children.
? Do not store above 25C. Store in the original package
Mechanism of Action : Gliclazide stimulates insulin secretion from pancreatic beta cells, which helps to lower blood sugar levels.
Metformin reduces hepatic glucose production, enhances peripheral glucose uptake and utilization, and decreases intestinal glucose absorption.
Therapeutic : Anti Diabetic
Side Effects : Hypoglycemia (low blood sugar)
Gastrointestinal symptoms such as nausea, diarrhea, or abdominal discomfort
Headache
Dizziness
Weight gain (less common with metformin)
Contraindications : "If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this
medicine.
You must not take this medicine while you are breast-feeding"
Safety Advice / Warnings : "This medicine be used with caution in elderly patients, as they may be more susceptible to hypoglycemia and other adverse effects.
Patients should be advised to avoid excessive alcohol consumption while taking Gliclazide, as alcohol may potentiate the risk of hypoglycemia.
Tablets are not recommended for use during pregnancy.
If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this
medicine.
You must not take this medicine while you are breast-feeding
Drinking alcohol is not recommended as it can alter the control of your diabetes in an unpredictable manner"""
References : Product Information: RIOMET ER(TM) oral extended-release suspension, metformin HCl oral extended-release suspension. Sun Pharmaceutical Industries Inc (per FDA), Cranbury, NJ, 2019.
Product Information: GLUMETZA(R) oral extended-release tablets, metformin HCl oral extended-release tablets. Valeant Pharmaceuticals of North America (per FDA), Bridgewater, NJ, 2017.
"https://www.drugs.com/uk/pdf/leaflet/1084506.pdf (Zircon product leaflet)
Bressler R & Johnson DG: Pharmacological regulation of blood glucose levels in non-insulin-dependent diabetes mellitus. Arch Intern Med 1997; 157:836-848.
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