Product Details
VILDAGLIPTIN 50 MG + METFORMIN HYDROCHLORIDE 1000 MG
Introduction : This combination of Vildagliptin 50mg and Metofromin 1000mg tablet medication is indicated for the treatment of type 2 diabetes mellitus (T2DM) in adults who have not achieved adequate glycemic control with metformin alone or who are already taking vildagliptin and metformin separately.
This helps prevent serious complications of diabetes such as kidney damage and blindness and may also reduce your chances of having a heart attack or stroke.
Vildagliptin 50mg and Metofromin 1000mg tablet is indicated for the treatment of type 2 diabetes mellitus in adults as monotherapy or in combination with insulin.
Indication : Vildagliptin 50 mg: Vildagliptin is an oral antidiabetic medication that belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors. It helps lower blood sugar levels by inhibiting the enzyme DPP-4, which degrades incretin hormones that regulate insulin secretion.
Metformin Hydrochloride 1000 mg: Metformin is a biguanide antidiabetic drug that reduces glucose production in the liver, increases insulin sensitivity in peripheral tissues, and improves glucose uptake by muscles.
Administration : It is typically taken orally twice daily with meals or as directed by a healthcare professional.
While taking the extended-release tablet, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.
Storage : Store the medication at room temperature, away from moisture, heat, and direct sunlight.
Mechanism of Action : Vildagliptin increases insulin secretion and suppresses glucagon release in a glucose-dependent manner by inhibiting the enzyme DPP-4, which leads to improved glycemic control.
Metformin primarily works by reducing hepatic glucose production, enhancing insulin sensitivity in peripheral tissues, and improving glucose uptake by muscles, thereby lowering blood sugar levels.
Therapeutic : Antidiabetic
Side Effects : Gastrointestinal disturbances such as nausea, vomiting, diarrhea, or abdominal discomfort
fatigue, constipation,Headache
Hypoglycemia (low blood sugar levels) when used in combination with insulin secretagogues or insulin
Upper respiratory tract infections
Contraindications : "Acute or chronic metabolic acidosis including diabetic ketoacidosis
Severe renal impairment"
Safety Advice / Warnings : Alcohol?Drinking alcohol may cause severe low blood sugar. Discuss this with your health care team.
Other medicines?Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems.
Hyperglycemia (high blood sugar) may occur if you do not take enough or skip a dose of your medicine, overeat or do not follow your meal plan, have a fever or infection, or do not exercise as much as usual. High blood sugar can be very serious and must be treated right away. It is important that you learn which symptoms you have in order to treat it quickly. Talk to your doctor about the best way to treat high blood sugar.
Avoid use of this drug during pregnancy and prescribe an alternative. Evidence has demonstrated fetal abnormalities or risks when used during pregnancy. Advise women of childbearing potential of fetal risk.
Dizziness, lightheadedness, or fainting may occur with this medicine. Drink plenty of water during exercise or in hot weather. Check with your doctor if you have severe nausea, vomiting, or diarrhea that does not stop. This may cause you to lose too much water.
References : Product Information: Jalra oral tablets, vildagliptin oral tablets. Novartis Europharm Limited (per EMA), Camberley, United Kingdom, 2015.
Product Information: Galvus oral tablets, vildagliptin oral tablets. Novartis Europharm Limited (per EMA), Camberley, United Kingdom, 2016.
"Product Information: GLUCOPHAGE(R) oral tablets, metformin HCl oral tablets. Bristol-Myers Squibb Company (per FDA), Princeton, NJ, 2017.
Product Information: Metformin Juta oral tablet, metformin hydrochloride oral tablet. Juta Pharma GmbH (per AEMPS;Spain), Gutenbergstrasse 13, 24941 Flensburg, Germany, 2019."