Product Details
DUTASTERIDE 0.5 MG
Introduction : Dutasteride 0.5mg tablet is used alone or in combination with tamsulosin to treat men who have symptoms of an enlarged prostate gland, which is also known as benign prostatic hyperplasia (BPH). Benign enlargement of the prostate is a problem that can occur in men as they get older. The prostate gland is located below the bladder. As the prostate gland enlarges, certain muscles in the gland may become tight and get in the way of the tube that drains urine from the bladder. This can cause problems with urinating, such as a need to urinate often, a weak stream when urinating, or a feeling of not being able to empty the bladder completely.
Dutasteride 0.5mg tablet blocks the action of an enzyme called 5-alpha-reductase. This enzyme changes testosterone to another hormone that causes the prostate to grow. As a result, the size of the prostate is decreased. The effect of dutasteride lasts only as long as the medicine is taken. If it is stopped, the prostate begins to grow again.
This medicine is available only with your doctors prescription.
Indication : Dutasteride 0.5mg tablet is used in men to treat the symptoms of an enlarged prostate (benign prostatic hyperplasia-BPH). It works by reducing the size of the enlarged prostate. This helps to relieve symptoms of BPH such as difficulty in beginning the flow of urine, weak stream, and the need to urinate often or urgently (including during the middle of the night). It may also reduce the need for surgery to treat BPH.
Dutasteride 0.5mg tablet is not approved for prevention of prostate cancer. It may slightly increase the risk of developing a very serious form of prostate cancer.
Administration : take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
You may take this medicine with or without food.
Swallow the capsule whole. Do not crush, chew, or open it. The contents of the capsule may irritate your lips, mouth, or throat.
Storage : Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Mechanism of Action : Systemic: Dutasteride inhibits the conversion of testosterone to 5?-dihydrotestosterone (DHT). DHT is the androgen primarily responsible for the initial development and subsequent enlargement of the prostate gland. Testosterone is converted to DHT by the enzyme 5?-reductase, which exists as 2 isoforms, type 1 and type 2. Type 2 isoenzyme is primarily active in the reproductive tissue while type 1 isoenzyme is responsible for testosterone conversion in the skin and liver.
Therapeutic : Benign Prostatic Hypertrophy Agent
Side Effects : Side effects may include impotence, decreased libido, ejaculation disorders, and breast enlargement and/or tenderness
Contraindications : Evidence has demonstrated fetal abnormalities or risks when used during pregnancy.
Safety Advice / Warnings : Note: Women of childbearing potential should not use or handle dutasteride capsules. Dutasteride can cause birth defects in male fetuses.
In Liver disease?Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Women and children should not use this medicine. Pregnant women or women who may become pregnant should not handle or touch the capsules. Dutasteride can be absorbed through the skin and can cause birth defects in male fetuses. If a pregnant woman does come in contact with this medicine, the affected area should be washed right away with soap and water, especially if the capsule is broken.
Men who have taken this medicine should not donate blood until 6 months have passed since the last dose. Dutasteride can remain in your blood for a long time and be passed on to a pregnant woman who receives a blood transfusion.
References : Product Information: AVODART(R) oral capsules, dutasteride oral capsules. GlaxoSmithKline (Per FDA), Research Triangle Park, NC, 2011.
Product Information: Avodart?, dutasteride. GlaxoSmithKline, Research Triangle Park, NC, 2003.
Tsai TF, Choi GS, Kim BJ, et al: Prospective randomized study of sexual function in men taking dutasteride for the treatment of androgenetic alopecia. J Dermatol 2018; 45(7):799-804.
PubMed Abstract: http://www.ncbi.nlm.nih.gov/...