Product Details
NICORANDIL 5 MG
Introduction : Nicorandil 5mg tablet is a medication used to treat angina pectoris, a condition characterized by chest pain or discomfort due to reduced blood flow to the heart muscle.
Nicorandil 5mg tablet helps in prevention as well as treatment of angina. Angina is a chest pain that is usually caused by the narrowing of the blood vessels which supply your heart. This means your heart does not get enough oxygen. Nicorandil 5mg tablet relaxes and widens the blood vessels so more blood (and oxygen) gets to your heart. This reduces the pain and discomfort that angina causes thereby improving your ability to exercise and go about your daily life more easily. This medicine needs to be taken regularly to be effective so keep taking it even if you are not having any angina symptoms.
Indication : Nicorandil 5mg tablet medicine used to prevent and treat heart-related chest pain (angina). It is usually prescribed when other heart medicines are either not suitable or have not worked. It reduces the risk of an angina attack by widening blood vessels and improving blood flow to the heart.
Administration : You may take this medicine with or without food.
Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
Storage : Store in a refrigerator (2 - 8?C). Do not freeze.
away from heat, moisture, and direct light.
Side Effects : common side effects of Nicorandil may include headache, dizziness, flushing, palpitations, and gastrointestinal disturbances such as nausea and vomiting.
Contraindications : Avoid use of this drug during pregnancy and prescribe an alternative. Evidence has demonstrated fetal abnormalities or risks when used during pregnancy
Evidence and/or expert consensus has demonstrated harmful infant effects when used during breastfeeding
Safety Advice / Warnings : It may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Avoid consumption of alcohol while taking this medicine
Nicorandil should be used with caution in patients with hypotension, severe renal impairment, or hepatic impairment
References : Nicorandil. Macquarie Park, New South Wales: Sanofi-Aventis Australia Pty Ltd.; 2017.
Katzung BG, Chatterjee K. Vasodilator & the Treatment of Angina Pectoris. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 198.
Nicorandil [patient Information Sheet]. Ahmedabad, Gujarat: Torrent Pharmaceuticals Ltd.
Mechanism of Action : Nicorandil works through two mechanisms:
It acts as a potassium channel opener, causing relaxation of vascular smooth muscle and dilation of both coronary and peripheral arteries, thereby increasing blood flow to the heart muscle.
It also has nitrate-like effects, releasing nitric oxide (NO) in the blood vessels, which further promotes vasodilation and reduces cardiac workload.
Therapeutic : Cardiovascular agent