Sacubitril 24 Mg + Valsartan 26 Mg

Administer orally with or without food. Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Store the medicine at room temperature, away from heat, moisture, and direct light. Keep out of the reach of children.

Side effects may include Hyperkalemia (high potassium levels), cough, dizziness, or renal failure, Fatigue, Cough, Increased serum creatinine levels.

Avoid use of this drug during pregnancy. Evidence has demonstrated risks when used during pregnancy and breastfeeding.

Do not take this medicine for at least 36 hours before or after you take an ACE inhibitor medicine. Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy. If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning. Ask your doctor before you use medicines, supplements, or salt substitutes that contain potassium. Use caution in patients with renal impairment or on dialysis, as the risk of hyperkalemia may be increased. Monitor blood pressure, renal function, and electrolytes regularly during treatment.

Product Information: ENTRESTO(TM) oral tablets, sacubitril valsartan oral tablets. Novartis Pharmaceuticals Corporation (per Manufacturer), East Hanover, NJ, 2015. Farak's J, Du Y, Bedman T, et al: Disposition and metabolism of [(14)C] sacubitril/valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects. Xenobiotic 2016; 46(11):986-1000.

Sacubitril: It is a neprilysin inhibitor. Neprilysin is an enzyme responsible for breaking down natriuretic peptides, which play a role in regulating blood pressure and fluid balance. By inhibiting neprilysin, sacubitril increases the levels of natriuretic peptides, resulting in vasodilation and natriuresis, which helps reduce blood pressure and improve heart failure symptoms. Valsartan: It is an angiotensin II receptor blocker (ARB). Valsartan blocks the action of angiotensin II, a hormone that causes blood vessels to constrict, thereby reducing blood pressure and workload on the heart.

angiotensin receptor-neprilysin inhibitors (ARNIs).