Product Details
TRYPSIN 48 MG + BROMELAIN 90 MG + RUTOSIDE TRIHYDRATE 100 MG + DICLOFENAC SODIUM 50 MG
Introduction : The combination of Tryspin 48 Mg + Bromelain 90 Mg + Rutoside Trihydrate 100 Mg + Diclofenac Sodium 50 Mg tablets is used to reduce pain and inflammation in conditions like rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. It may also be used to relieve fever, muscle pain, back pain, toothache, or pain in the ear and throat.
The anti-inflammatory and analgesic properties of Diclefenac help reduce pain and inflammation associated with these conditions, while Trypsin and Bromelain aid in the breakdown of inflammatory proteins and facilitate tissue repair. Rutoside trihydrate may also contribute to reducing inflammation and swelling.
Another common use is in the treatment of soft tissue injuries, including sprains and strains. The combinations anti-inflammatory effects help alleviate swelling and pain associated with soft tissue injuries, while its proteolytic enzymes, such as Trypsin and Bromelain, promote tissue healing and reduce recovery time.
Indication : This combination is commonly indicated for the treatment of various conditions involving inflammation, pain, and edema, such as:
Musculoskeletal disorders (e.g., osteoarthritis, rheumatoid arthritis)
Soft tissue injuries (e.g., sprains, strains)
Postoperative inflammation and pain
Sports injuries
Muscle Spasms and Inflammation
Administration : Usually taken after food, to avoid gastric disturbances
Take it as prescribed to get the most benefit.
Storage : Store the medication at room temperature, away from moisture and heat.
Mechanism of Action : Trypsin (48 mg): Trypsin is a proteolytic enzyme that helps in the breakdown of proteins.
Bromelain (90 mg): Bromelain is a mixture of proteolytic enzymes derived from pineapple stems.
Rutoside trihydrate (100 mg): Rutoside is a flavonoid compound known for its anti-inflammatory and antioxidant properties.
Therapeutic : Anti Inflammatory
Side Effects : Common side effects of this combination may include:
Gastrointestinal disturbances (e.g., nausea, indigestion, abdominal pain)
Allergic reactions (e.g., skin rash, itching)
Headache
Dizziness
Increased risk of bleeding (especially with NSAIDs like Aceclofenac)
Contraindications : Evidence has demonstrated fetal abnormalities or risks when used during pregnancy
Evidence has demonstrated harmful infant effects when used during breastfeeding.
Safety Advice / Warnings : Patients with a history of gastrointestinal ulcers, bleeding disorders, or kidney dysfunction should use this combination with caution.
Long-term use of NSAIDs like Aceclofenac may increase the risk of gastrointestinal bleeding, ulcers, and cardiovascular events.
Avoid consumtpion of alcohol and smoking
Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
References : "Hale LP, Greer PK, Trinh CT, Gottfried MR. Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease. Clin Immunol. 2005 Aug;116(2):135-42.
Shah D, Mital K. The Role of Trypsin:Chymotrypsin in Tissue Repair. Adv Ther. 2018;35(1):31-42. [Accessed 22 Apr. 2019]
Drugs.com. Rutin. [Accessed 22 Apr. 2019] "