Product Details
ATENOLOL 25 MG
Introduction : Atenolol is primarily prescribed for the treatment of hypertension. It may also be used for the management of angina (chest pain) and to prevent heart attacks.
Indication : Atenlol 25mg is indicated in the management of hypertension.
It may be used alone or concomitantly with other
antihypertensive agents, particularly with a thiazide-type
diuretic.
Atenlol 25mg is indicated for the long-term management of
patients with angina pectoris.
Atenlol 25mg is indicated in the management of
hemodynamically stable patients with definite or suspected
acute myocardial infarction to reduce cardiovascular
mortality.
Administration : Patient should avoid activities requiring mental alertness or coordination until drug effects are realized, as drug may cause dizziness.
This drug may cause bradyarrhythmia, cold extremities, fatigue, insomnia, or depression.
Advise patient to report signs/symptoms of cardiac failure.
Drug may mask symptoms of hypoglycemia. Advise diabetic patients to carefully follow blood sugar levels.
Advise patient against sudden discontinuation of drug especially when being treated for angina. Abrupt withdrawal may cause rebound angina.
Patient should take drug on an empty stomach.
Instruct patient to take a missed dose as soon as possible, but if next dose is in less than 8 h, skip the missed dose.
Storage : Store at controlled room temperature, between 20 and 25 degrees C (68 and 77 degrees F). Protect from light
Side Effects : Most adverse effects have been mild and transient.
Bradyarrhythmia,
Cold extremity,
Hypotension,
Dizziness
Depression
Fatigue
Contraindications : Atenolol 25mg is contraindicated in sinus bradycardia, heart block greater than first degree, cardiogenic shock, and overt cardiac failure
Safety Advice / Warnings : Cardiovascular: Cardiac failure may occur even in patients without history of cardiac failure; discontinuation may be necessary
Cardiovascular: Congestive heart failure; potential risk for further myocardial contractility depression and worsening of heart failure
Concomitant Use: Withdrawal of concomitant clonidine therapy; atenolol may increase risk of rebound hypertension and should be discontinued several days before clonidine is withdrawn
Endocrine and Metabolic: Diabetes mellitus; may mask symptoms of hypoglycemia (eg, tachycardia)
Endocrine and Metabolic: Hyperthyroidism; symptoms such as tachycardia may be masked and abrupt withdrawal may precipitate thyroid storm
References : [99] Product Information: TENORMIN(R) oral tablets, atenolol oral tablets. AstraZeneca Pharmaceuticals LP, Wilmington, DE, 2008.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/018240s031lbl.pdf
Krittayaphong R, Bhuripanyo K, Punlee K, et al: Effect of atenolol on symptomatic ventricular arrhythmia without structural heart disease: a randomized placebo-controlled study. Am Heart J 2002; 144(6):e10.
Mechanism of Action : Atenolol is a synthetic beta(1)-selective adrenoreceptor blocking agent without membrane stabilizing or intrinsic sympathomimetic activities. It inhibits beta(2)-adrenoreceptors primarily found in bronchial and vascular musculature at higher doses