Bisoprolol 2.5 Mg + Amlodipine 5 Mg

Take once daily or as prescribed by your doctor. Can be taken with or without food. Take at the same time each day for better control. Swallow the tablet whole with water. Do not stop the medication suddenly without medical advice, especially due to the bisoprolol component.

Store below 25–30°C. Keep in a dry place away from moisture and direct sunlight. Keep out of reach of children.

Common Dizziness or lightheadedness Fatigue Slow heart rate Swelling of ankles or feet (due to amlodipine) Headache Flushing Less Common but Serious Very low blood pressure Severe bradycardia Shortness of breath or worsening heart failure Allergic reactions Seek medical attention if severe symptoms occur.

Abrupt discontinuation of beta-blockers may worsen angina or cause cardiac complications. Driving Avoid driving if you feel dizzy or tired. Pregnancy & Breastfeeding Use only if prescribed after medical evaluation.

Patient should avoid activities requiring mental alertness or coordination until drug effects are realized. This drug may cause bradyarrhythmia, cold extremities, hypotension, dyspepsia, dizziness, headache, dyssomnia, upper respiratory infection, or fatigue. Drug may mask symptoms of hypoglycemia. Advise diabetic patients to carefully monitor blood sugar levels. Advise patient against sudden discontinuation of drug. Instruct patient to take a missed dose as soon as possible, but if next dose is in less than 8 h, skip the missed dose.

Norvasc (amlodipine besylate) tablets label ; Amlodipine besylate [FDA Label]. New York, NY: Pfizer Labs.; 1987 [revised May 2011]. [Accessed 14 Mar. 2019] (online) Available from:External Link"" Product Information: bisoprolol fumarate oral tablet. TEVA PHARMACEUTICALS, Sellersville, PA, 2003. Schliep HJ & Harting J: Beta1-selectivity of bisoprolol, a new beta-adrenoceptor antagonist in aneasthetized dogs and guinea pigs. J Cardiovasc Pharmacol 1984; 6:1156-1160. Product Information: Bisoprolol Fumarate oral tablets, bisoprolol fumarate oral tablets. Solco Healthcare US LLC (per DailyMed), Somerset, NJ, 2023.

Bisoprolol fumarate, a cardioselective inhibitor of beta(1)-adrenoceptor, has no significant intrinsic sympathomimetic activity or membrane stabilizing activity in its therapeutic dosage. It also exhibits beta(2)-adrenoceptor inhibition and a negative chronotropic effect Amlodipine is a dihydropyridine calcium channel blocker that exerts its effect by blocking the transmembrane influx of calcium ions into cardiac and vascular smooth muscles. It also reduces peripheral vascular resistance and lowers blood pressure by acting directly on vascular smooth muscle. Its therapeutic effect on angina may be through a decrease in peripheral resistance (exertional angina) and inhibition of coronary spasm (vasospastic angina)

Cardiac