Product Details
RANOLAZINE SR 500 MG
Introduction : Ranolazine 500mg SR (sustained release) tablet is used to treat chronic angina (chest pain). This medicine is usually used together with other medicines (eg, ACE inhibitors, angiotensin receptor blockers, calcium channel blockers, beta-blockers, nitrates, antiplatelets, or lipid-lowering medicines).
This medicine is available only with your doctors prescription.
Indication : Ranolazine 500mg SR (sustained release) tablet is used for the management of angina (heart-related chest pain). It helps to prevent new attacks of angina but does not stop an acute attack, once started. It relieves chest pain by making the heart work more efficiently.
Administration : You may take this medicine with or without food.
Swallow the extended-release tablet and extended-release granules whole. Do not crush, break, or chew it.
The dose of this medicine will be different for different patients. Follow your doctors orders or the directions on the label.
Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
Avoid drinking alcohol while you are using the extended-release granules.
Storage : Store the medication at room temperature, away from moisture and heat.
Keep it out of reach of children
Side Effects : Side effects may include headache, dizziness, vomiting, nausea, or constipation
Contraindications : Evidence has demonstrated harmful infant effects when used during Pregnancy and breastfeeding.
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Safety Advice / Warnings : Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
Avoid drinking alcohol while you are using the extended-release granules.
If you will be taking this medicine for a long time, it is very important that your doctor check you at regular visits for any problems or unwanted effects that may be caused by this medicine.
Do not use this medicine to treat a sudden onset of chest pain.
This medicine may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.
References : Product Information: RANEXA(R) oral extended-release tablets, ranolazine oral extended-release tablets. Gilead Sciences Inc (per FDA), Foster City, CA, 2019.
Jerling M & Abdallah H: Effect of renal impairment on multiple-dose pharmacokinetics of extended-release ranolazine. Clin Pharmacol Ther 2005; 78:288-297.
Ranolazine Sustained Release Tablets [Package Insert]. Ahmedabad, Gujarat: Torrent Pharmaceuticals Ltd.; 2019.
Mechanism of Action : Ranolazine is a selective inhibitor of the late inward sodium current in cardiomyocytes. By reducing this current during ischemia, ranolazine helps to stabilize myocardial cell membrane potential and intracellular calcium levels, thereby improving myocardial relaxation and decreasing oxygen demand. This mechanism contributes to the antianginal effects of ranolazine.
Therapeutic : Antianginal