Dapagliflozin 10 Mg + Glimepride 2 Mg + Metformin (er) 500 Mg

It is typically taken orally, once daily, with a meal or as directed by a healthcare professional. Swallow the tablet or extended-release tablet whole with a full glass of water. Do not crush, break, or chew it. While taking the extended-release tablet, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

Store below 25–30°C. Keep in a dry place away from moisture and direct sunlight. Keep out of reach of children. Do not use after the expiry date.

This drug may cause nausea, asthenia, flu-syndrome, headache, or dizziness. urinary tract infections, genital yeast infections, increased urination, diarrhea, nausea, vomiting, difficulty in urination.

No use this medication in : Acute or chronic metabolic acidosis including diabetic ketoacidosis Severe renal impairment Avoid use of this drug during pregnancy and prescribe an alternative. Evidence has demonstrated fetal abnormalities or risks when used during pregnancy. Advise women of childbearing potential of fetal risk.

Alcohol—Drinking alcohol may cause severe low blood sugar. Discuss this with your health care team. Other medicines—Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems. Hyperglycemia (high blood sugar) may occur if you do not take enough or skip a dose of your medicine, overeat or do not follow your meal plan, have a fever or infection, or do not exercise as much as usual. High blood sugar can be very serious and must be treated right away. It is important that you learn which symptoms you have in order to treat it quickly. Talk to your doctor about the best way to treat high blood sugar. Dizziness, lightheadedness, or fainting may occur with this medicine. Drink plenty of water during exercise or in hot weather. Check with your doctor if you have severe nausea, vomiting, or diarrhea that does not stop. This may cause you to lose too much water.

Product Information: AMARYL(R) oral tablets, glimepiride oral tablets . Sanofi-Aventis U.S. LLC (per FDA), Bridgewater, NJ, 2016. Product Information: GLUCOPHAGE(R) oral tablets, metformin HCl oral tablets. Bristol-Myers Squibb Company (per FDA), Princeton, NJ, 2017. Product Information: Metformin Juta oral tablet, metformin hydrochloride oral tablet. Juta Pharma GmbH (per AEMPS;Spain), Gutenbergstrasse 13, 24941 Flensburg, Germany, 2019. Product Information: FORXIGA(R) oral tablets, dapagliflozin oral tablets. AstraZeneca Pharmaceuticals LP (per manufacturer), Wilmington, DE, 2021. Dandona P, Mathieu C, Phillip M, et al: Efficacy and safety of dapagliflozin in patients with inadequately controlled type 1 diabetes (DEPICT-1): 24 week results from a multicentre, double-blind, phase 3, randomised controlled trial. Lancet Diabetes Endocrinol 2017; 5(11):864-876.

Dapagliflozin inhibits sodium-glucose co-transporter 2 (SGLT2) in the proximal renal tubules, reducing glucose reabsorption and increasing urinary glucose excretion. Glimepiride stimulates insulin secretion from pancreatic β-cells by binding to the sulfonylurea receptor (SUR1) and inhibiting ATP-sensitive potassium channels. Metformin reduces hepatic gluconeogenesis and improves peripheral insulin sensitivity through activation of AMP-activated protein kinase (AMPK).

Anti Diabetic