Dapagliflozin 10 Mg + Vildagliptin (sr) 100 Mg + Metformin Hydrochloride (sr) 1000 Mg

It is typically taken orally, once daily, with a meal or as directed by a healthcare professional. Swallow the tablet or extended-release tablet whole with a full glass of water. Do not crush, break, or chew it. While taking the extended/sustained -release tablet, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

Store below 25–30°C. Keep in a dry place away from moisture and direct sunlight. Keep out of reach of children. Do not use after the expiry date.

This drug may cause nausea, asthenia, flu-syndrome, headache, or dizziness. urinary tract infections, genital yeast infections, increased urination, diarrhea, nausea, vomiting, difficulty in urination.

No use this medication in : Acute or chronic metabolic acidosis including diabetic ketoacidosis Severe renal impairment Avoid use of this drug during pregnancy and prescribe an alternative. Evidence has demonstrated fetal abnormalities or risks when used during pregnancy. Advise women of childbearing potential of fetal risk.

Alcohol—Drinking alcohol may cause severe low blood sugar. Discuss this with your health care team. Other medicines—Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems. Hyperglycemia (high blood sugar) may occur if you do not take enough or skip a dose of your medicine, overeat or do not follow your meal plan, have a fever or infection, or do not exercise as much as usual. High blood sugar can be very serious and must be treated right away. It is important that you learn which symptoms you have in order to treat it quickly. Talk to your doctor about the best way to treat high blood sugar. Dizziness, lightheadedness, or fainting may occur with this medicine. Drink plenty of water during exercise or in hot weather. Check with your doctor if you have severe nausea, vomiting, or diarrhea that does not stop. This may cause you to lose too much water.

Product Information: Jalra oral tablets, vildagliptin oral tablets. Novartis Europharm Limited (per EMA), Camberley, United Kingdom, 2015. Product Information: Metformin Juta oral tablet, metformin hydrochloride oral tablet. Juta Pharma GmbH (per AEMPS;Spain), Gutenbergstrasse 13, 24941 Flensburg, Germany, 2019. Product Information: Galvus oral tablets, vildagliptin oral tablets. Novartis Europharm Limited (per EMA), Camberley, United Kingdom, 2016. Scheen AJ, Tan MH, Betteridge DJ, et al. Long-term glycaemic efficacy and weight changes with dapagliflozin versus sitagliptin add-on in inadequately controlled type 2 diabetes on metformin """"Product Information: FORXIGA(R) oral tablets, dapagliflozin oral tablets. AstraZeneca Pharmaceuticals LP (per manufacturer), Wilmington, DE, 2021. Dandona P, Mathieu C, Phillip M, et al: Efficacy and safety of dapagliflozin in patients with inadequately controlled type 1 diabetes (DEPICT-1): 24 week results from a multicentre, double-blind, phase 3, randomised controlled trial. Lancet Diabetes Endocrinol 2017; 5(11):864-876.

Dapagliflozin selectively inhibits sodium-glucose co-transporter 2 (SGLT2) in the proximal renal tubules, reducing glucose reabsorption and increasing urinary glucose excretion. Vildagliptin inhibits dipeptidyl peptidase-4 (DPP-4), prolonging the activity of incretin hormones such as GLP-1 and GIP, which enhance glucose-dependent insulin secretion and suppress glucagon release. Metformin activates AMP-activated protein kinase (AMPK), reducing hepatic gluconeogenesis and improving peripheral insulin sensitivity.

Anti Diabetic