Product Details
ETORICOXIB 60 MG + PARACETAMOL 325 MG
Introduction : Etoricoxib 60 Mg + Paracetamol 325 Mg tablet is typically prescribed for the management of pain and inflammation associated with various conditions, such as:
Osteoarthritis: Etoricoxib and paracetamol combination can help alleviate pain and improve joint function in patients with osteoarthritis, a degenerative joint disease characterized by joint pain and stiffness.
Rheumatoid Arthritis: This combination may also be used in the management of rheumatoid arthritis to relieve pain, inflammation, and stiffness associated with the condition.
Acute Pain: Etoricoxib and paracetamol combination can be used for the short-term management of acute pain, such as postoperative pain or pain due to injuries.
Indication : This combination of Etoricoxib 60 Mg + Paracetamol 325 Mg medication is frequently prescribed for the management of pain associated with osteoarthritis, a degenerative joint disease characterized by joint pain, stiffness, and reduced mobility.
Etoricoxib and paracetamol combination can also be used for the short-term management of acute pain, such as postoperative pain or pain due to injuries.
Administration : Administer orally with a full glass of water, as directed by the healthcare provider. The tablet can be taken with or without food. Do not crush or chew the tablet; swallow it whole.
Storage : Store the medicine at room temperature, away from heat, moisture, and direct light.
Keep out of the reach of children.
Mechanism of Action : Etoricoxib: It is a selective cyclooxygenase-2 (COX-2) inhibitor that works by blocking the action of the enzyme COX-2, thereby reducing the production of prostaglandins, which are mediators of pain and inflammation.
Paracetamol: It is a centrally acting analgesic and antipyretic agent that inhibits prostaglandin synthesis in the central nervous system, leading to pain relief and reduction of fever.
Therapeutic : Analgesics and Anti inflammatory
Side Effects : Nausea
Abdominal pain
Diarrhea
Headache
Dizziness
Fatigue
Skin rash
Elevated liver enzymes (with prolonged use or overdose of paracetamol)
Contraindications : Avoid use of this drug during pregnancy Evidence has demonstrated fetal abnormalities or risks when used during pregnancy.
Evidence has demonstrated harmful infant effects when used during breastfeeding.
Safety Advice / Warnings : It May Cause Dizziness And Fatigue In A Few Cases. So, It Is Suggested To Avoid Driving Or Working On Heavy Machinery.
Also, Lactating Mothers Or Pregnant Women Should Avoid Taking This Medicine. If Necessary, Take It Only After The Doctor?s Prescription.
Lastly, Serious Side Effects Of Etoricoxib Are Liver Damage, High Blood Pressure, And Kidney Damage In Case Of Prolonged Usage.
Avoid alcohol consumption while taking this medication, as it may increase the risk of liver toxicity associated with paracetamol.
Monitor liver function tests periodically in patients receiving long-term treatment with paracetamol-containing medications.
References : Riendeau D, Percival MD, Brideau C, et al: Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2. J Pharmacol Exp Ther 2001; 296(2):558-566.
Sorbera LA, Castaner RM, Silvestre J, et al: Etoricoxib. Drugs Future 2001; 26(4):346-353.
"US Food & Drug Administration (FDA): Dont double up on acetaminophen. US Food & Drug Administration (FDA). Silver Spring, MD. 2018.
U.S. National Library of Medicine. Paracetamol. [Online] Available at: https://pubchem.ncbi.nlm.nih.gov/compound/Paracetamol. Accessed on January 20, 2024.
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