Product Details
AMLODIPINE 10 MG
Introduction : Amlodipine 10mg is a calcium channel blocker and may be used alone or in combination with other antihypertensive and antianginal agents for the treatment of: ? Hypertension ? Coronary Artery Disease ( Chronic Stable Angina o Vasospastic Angina (Prinzmetal?s or Variant Angina) o Angiographically Documented Coronary Artery Disease in patients without heart failure or an ejection fraction (we need to add here)
Indication : amlodipine 10mg is a type of medicine known as a calcium channel blocker (CCB). It is used to treat high blood pressure (hypertension) and angina (a type of chest pain) . It can be used by itself or with other medicines to treat these conditions. High Blood Pressure (hypertension) comes from blood pushing too hard against your blood vessels. Amlodipine 10mg relaxes your blood vessels, which lets your blood flow more easily and helps lower your blood pressure. Drugs that lower blood pressure also lower your risk of having a stroke or heart attack. Angina is a pain or discomfort that comes when part of your heart does not get enough blood. Angina feels like a pressing or squeezing pain, usually in your chest under the breastbone. Sometimes you can feel it in your shoulders, arms, neck, jaws, or back. Amlodipine 10mg can relieve this pain.
Administration : Dosage recommendations may vary, and it is essential to follow the specific dosage prescribed by a healthcare professional.
Storage : Keep amlodipine away from children. Store amlodipine Tablets
at room temperature (between 59? and 86?F). Keep amlodipine
out of the light. Keep amlodipine in a dry place.
Side Effects : may cause the following side effects. Most side effects are mild or moderate: ? headache ? swelling of your legs or ankles (oedema) ? tiredness, extreme sleepiness ? stomach pain, nausea ? dizziness ? flushing (hot or warm feeling in your face) ? arrhythmia (irregular heartbeat) ? heart palpitations (very fast heartbeat)
Contraindications : is contraindicated in patients with known sensitivity to amlodipine.
References : Norvasc (amlodipine besylate) tablets label ;
Amlodipine besylate [FDA Label]. New York, NY: Pfizer Labs.; 1987 [revised May 2011]. [Accessed 14 Mar. 2019] (online) Available from:External Link
Mechanism of Action : Amlodipine is a dihydropyridine calcium channel blocker that exerts its effect by blocking the transmembrane influx of calcium ions into cardiac and vascular smooth muscles. It also reduces peripheral vascular resistance and lowers blood pressure by acting directly on vascular smooth muscle. Its therapeutic effect on angina may be through a decrease in peripheral resistance (exertional angina) and inhibition of coronary spasm (vasospastic angina)