Product Details
OLMESARTAN MEDOXOMIL 20 MG + METOPROLOL SUCCINATE 50 MG (ER)
Introduction : Olmesartan 20mg + Metoprolol 50mg ER (extended release) combination tablets are indicated for the treatment of hypertension in adults who require combination therapy to achieve blood pressure control.
Olmesartan is an angiotensin II receptor blocker (ARB). It works by blocking a substance in the body that causes the blood vessels to tighten. Olmesartan relaxes the blood vessels and lowers blood pressure. A lower blood pressure will increase the supply of blood and oxygen to the heart.
Metoprolol is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart.
Indication : Olmesartan 20mg + Metoprolol 50mg ER (extended release) is primarily prescribed for the treatment of hypertension (high blood pressure) in adults.
It is particularly beneficial for individuals whose blood pressure is not adequately controlled with monotherapy or who require combination therapy to achieve target blood pressure levels. By lowering blood pressure, this medication helps reduce the risk of cardiovascular events such as heart attacks, strokes, and other complications associated with hypertension.
Administration : You may take this medicine with or without food.
Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor or pharmacist if you have any questions.
Storage : Protect from moisture or light and store below 30 degrees Celsius (C))
Mechanism of Action : Olmesartan is an angiotensin II receptor blocker (ARB) that works by blocking the action of angiotensin II, a substance in the body that causes blood vessels to constrict, thereby relaxing blood vessels and lowering blood pressure.
Metoprolol (ER) is a beta-blocker that works by blocking the effects of certain natural chemicals in the body, such as epinephrine, on the heart and blood vessels. This results in a slowing of the heart rate, reducing the workload on the heart and lowering blood pressure.
Therapeutic : Cardiovascular Agent
Side Effects : Dizziness, headache, fatigue, hypotension (low blood pressure), bradycardia (slow heart rate), and gastrointestinal disturbances.
Contraindications : "Evidence has demonstrated fetal abnormalities or risks when used during pregnancy and breast feeding. consult with doctor immidaitely
Safety Advice / Warnings : Using this medicine while you are pregnant can harm your unborn baby.
Dizziness or lightheadedness may occur after the first dose of this medicine, especially if you have been taking a diuretic (water pill). Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy.
n addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of food you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should first check with your doctor before changing your diet.
This medicine may cause changes in blood sugar levels. Also, this medicine may cover up the symptoms of low blood sugar (including fast heartbeat) and increase the risk for serious or prolonged hypoglycemia (low blood sugar). Check with your doctor if you notice a change in your normal symptoms or a change in the results of your blood or urine sugar tests.
References : Product Information: Lopressor(R) oral tablets, metoprolol tartrate oral tablets. Validus Pharmaceuticals, LLC (per FDA), Parsippany, NJ, 2013.
"Product Information: BENICAR(R) oral tablets, olmesartan medoxomil oral tablets. Daiichi Sankyo, Inc. (per FDA), Parsippany, NJ, 2013.
Barrios V, Boccanelli A, Ewald S, et al: Efficacy and tolerability of olmesartan medoxomil in patients with mild to moderate essential hypertension: the OLMEBEST Study. Clin Drug Investig 2007; 27(8):545-558."