Clotrimazole 1 % W/w + Iodochlorohydroxyquinoline 1 % W/w + Tolnafate 1 % W/w + Gentamycin 0.1 % W/w + Clobetasol 0.05 % W/w + Chlorocresol 0.1 % W/w Cream

The cream should be applied evenly to the affected area(s) of the skin, usually twice daily or as directed by a healthcare professional. Wash and dry the affected area(s) of the skin before applying the cream. It is important to follow the instructions provided by your healthcare provider or pharmacist.

Store the cream at room temperature, away from moisture and heat. Keep it out of reach of children.

Skin irritation, Burning or stinging sensation at the application site, Dryness or peeling of the skin.

NA

Avoid contact with the eyes and mucous membranes. Do not use the cream for longer than prescribed or apply it to large areas of the skin without medical supervision. Only for external use.

OTC Product Information: CLOTRIMAZOLE, topical liquid 1%, clotrimazole, topical liquid 1%. Pedifix, Brewster, NY, as posted to the DailyMed site 05/2014. OTC Product Information: CLOTRIMAZOLE ANTIFUNGAL, topical cream, clotrimazole, topical cream 1%. Actavis Pharma, Inc, Parsippany, NJ, as posted to the DailyMed site 12/2017. Gupta AK, Chaudhry MM. The Carotid Artery Model: A Highly Reproducible and Clinically Relevant Model to Measure Murine Atherosclerosis. JoVE. 2019;(146):e59370. doi:10.3791/59370.

Clotrimazole: It works by inhibiting the synthesis of ergosterol, an essential component of the fungal cell membrane. This disruption in ergosterol synthesis leads to alterations in membrane permeability and ultimately results in fungal cell death. Iodochlorohydroxyquinoline: It disrupts the cell membrane integrity of fungi and bacteria, leading to their death. It interferes with various cellular processes essential for the survival of these microorganisms. Tolnaftate: It works by inhibiting the enzyme squalene epoxidase, which is involved in the synthesis of ergosterol in fungal cell membranes. By disrupting ergosterol synthesis, tolnaftate impairs fungal cell membrane integrity and function, ultimately leading to fungal cell death. Gentamicin: It works by binding to the bacterial ribosome and inhibiting protein synthesis, leading to bacterial cell death. Gentamicin is effective against a wide range of Gram-negative and some Gram-positive bacteria. Clobetasol: Clobetasol suppresses the production of pro-inflammatory cytokines, inhibits the migration of inflammatory cells, and reduces the release of inflammatory mediators, thereby alleviating inflammation, itching, redness, and swelling associated with inflammatory skin conditions. Chlorocresol: It helps prevent microbial contamination of the cream formulation, thereby ensuring its stability and efficacy throughout its shelf life.

Anti-Fungal