Product Details
OLMESARTAN MEDOXOMIL 20 MG + AMLODIPINE 5 MG + HYDROCHLOROTHIAZIDE 12.50 MG
Introduction : Olmesartan 20mg, amlodipine 5mg, and hydrochlorothiazide 12.5mg tablets is a combination of medicines that may be used alone or with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure can reduce the risk of strokes and heart attacks.
Olmesartan is an angiotensin II receptor blocker (ARB). It works by blocking a substance in the body that causes the blood vessels to tighten. Olmesartan relaxes the blood vessels and lowers blood pressure. A lower blood pressure will increase the supply of blood and oxygen to the heart.
Amlodipine is a calcium channel blocker (CCB). It affects the movement of calcium into the cells of the heart and blood vessels. Amlodipine relaxes the blood vessels and lowers blood pressure.
Hydrochlorothiazide is a thiazide diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine. This helps lower blood pressure.
This medicine is available only with your doctors prescription.
Indication : Olmesartan 20mg, amlodipine 5mg, and hydrochlorothiazide 12.5mg tablets is primarily indicated for the treatment of hypertension (high blood pressure) in adults. It is often prescribed for individuals whose blood pressure is not adequately controlled with monotherapy or who require combination therapy to achieve target blood pressure levels. By lowering blood pressure, this medication helps reduce the risk of cardiovascular events such as heart attacks, strokes, and other complications associated with hypertension.
Cardiovascular Risk Reduction: In addition to lowering blood pressure, the combination of Olmesartan medoxomil, Amlodipine, and Hydrochlorothiazide may also provide cardiovascular protective effects. By improving vascular function and reducing blood pressure, this medication helps lower the risk of cardiovascular events, including myocardial infarction (heart attack), stroke, and heart failure. It may be particularly beneficial for patients at high risk of cardiovascular disease or those with additional risk factors such as diabetes or chronic kidney disease.
Administration : Swallow the tablet whole. Do not break, crush, or chew it. You may take this medicine with or without food.
In addition to taking this medicine, treatment for your high blood pressure may include weight control and a change in the foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you.
Storage : Protect from moisture or light and store below 30 degrees Celsius (C))
Side Effects : Bloating or swelling of the face, arms, hands, lower legs, or feet; rapid weight gain; tingling of the hands or feet; unusual weight gain or loss
electrolyte imbalances (such as low potassium levels), increased uric acid levels, and increased blood glucose levels.
Contraindications : "Evidence has demonstrated fetal abnormalities or risks when used during pregnancy and breast feeding. consult with doctor immidaitely
Safety Advice / Warnings : Using this medicine while you are pregnant can harm your unborn baby, especially in your second or third trimester. You may need to stop using this medicine.
This medicine may cause dizziness, lightheadedness, or fainting, especially when you get up suddenly from a lying or sitting position. be cautious before you drive, use machines, or do anything else that could be dangerous if you are dizzy. If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning.
Check with your doctor right away if you become sick while taking this medicine, especially if you have severe nausea, vomiting, or diarrhea that does not stop. These conditions may cause you to lose too much water and lead to low blood pressure. You can also lose water by sweating, so drink plenty of water during exercise or in hot weather.
This medicine may cause angina (chest pain). Check with your doctor right away if you are having chest pain or discomfort, fast or irregular heartbeat, nausea or vomiting, pain or discomfort in the arms, jaw, back, or neck, trouble breathing, or sweating.
Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, trouble breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.
Check with your doctor right away if blurred vision, difficulty with reading, eye pain, or any other change in vision occurs during or after treatment. This could be a sign of a serious eye problem.
This medicine may affect blood sugar levels. Diabetic patients may notice a change in the results of blood or urine glucose tests.
Severe, chronic diarrhea with weight loss may develop months to years after taking this medicine.
References : Product Information: TRIBENZOR(R) oral tablets, olmesartan medoxomil amlodipine hydrochlorothiazide oral tablets. Daiichi Sankyo, Inc. (per FDA), Parsippany, NJ, 2014.
Product Information: TRIBENZOR oral tablets, olmesartan medoxomil, amlodipine, hydrochlorothiazide oral tablets. Daiichi Sankyo Inc (per FDA), Parsippany, NJ, 2020.
Mechanism of Action : Olmesartan medoxomil is an angiotensin II receptor blocker (ARB) that works by blocking the action of angiotensin II, a substance in the body that causes blood vessels to constrict, thereby relaxing blood vessels and lowering blood pressure.
Amlodipine is a calcium channel blocker (CCB) that works by relaxing the blood vessels, allowing blood to flow more easily and reducing blood pressure.
Hydrochlorothiazide is a thiazide diuretic that works by increasing the excretion of sodium and water from the body, leading to reduced blood volume and decreased blood pressure.
Therapeutic : Antihypertensive