Olmesartan Medoxomil 40 Mg + Chlorthalidone 12.5 Mg + Cilnidipine 10 Mg

This combination of Olmesartan Medoxomil 40 Mg + Cilnidipine 10 Mg + Chlorthalidone 12.5 Mg medication is primarily used for the treatment of hypertension (high blood pressure). It helps lower blood pressure by targeting multiple mechanisms involved in blood pressure regulation. The combined action of these three medications helps achieve better blood pressure control and reduces the risk of cardiovascular complications associated with hypertension. In addition to its antihypertensive effects, this combination medication may also be used in the management of chronic kidney disease (CKD) associated with hypertension. Controlling blood pressure is essential in slowing the progression of CKD and reducing the risk of complications such as kidney failure, cardiovascular events, and mortality.

This medicine may be taken with or without food. In addition to taking this medicine, treatment for your high blood pressure may include weight control and a change in the foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you.

Protect from moisture or light and store below 30 degrees Celsius (C))

Dizziness, Headache, Fatigue, Hypotension (low blood pressure), Electrolyte disturbances (such as hypokalemia), Increased uric acid levels, Renal impairment, Hypersensitivity reactions, Gastrointestinal disturbances (such as nausea, vomiting, and diarrhea).

Evidence has demonstrated fetal abnormalities or risks when used during pregnancy and breastfeeding.

"""Using this medicine while you are pregnant can harm your unborn baby. Dizziness or lightheadedness may occur after the first dose of this medicine, especially if you have been taking a diuretic (water pill). Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy. Check with your doctor right away if you become sick while taking this medicine, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water, and may lead to low blood pressure. You can also lose water by sweating, so drink plenty of water during exercise or in hot weather. Severe, chronic diarrhea with weight loss may develop months to years after taking this medicine. Tell your doctor right away if you have these symptoms. Ask your doctor before you use medicines, supplements, or salt substitutes that contain potassium.

Product Information: BENICAR HCT(R) oral tablets, olmesartan medoxomil hydrochlorothiazide oral tablets. Daiichi Sankyo, Inc (per FDA), Parsippany, NJ, 202 Product Information: Chlorthalidone oral tablets, chlorthalidone oral tablets. Sun Pharmaceutical Industries Inc (per DailyMed), Cranbury, NJ, 2017. https://www.centaurpharma.com/downloads/CENTAPRES.pdf https://hypertension.ca/

Olmesartan Medoxomil: It is an angiotensin II receptor blocker (ARB) that works by blocking the action of angiotensin II, a hormone that causes blood vessels to constrict, thereby lowering blood pressure. Cilnidipine: It is a calcium channel blocker with dual action on L-type and N-type calcium channels. Cilnidipine causes vasodilation by inhibiting calcium influx into vascular smooth muscle cells, resulting in decreased peripheral vascular resistance and blood pressure. Chlorthalidone: It is a thiazide diuretic that promotes diuresis by inhibiting sodium reabsorption in the kidneys, leading to decreased blood volume and subsequent reduction in blood pressure.

Antihypertensive