Clotrimazole 1 % W/w + Iodochlorohydroxyquinoline 1 % W/w + Tolnafate 1 % W/w + Gentamycin 0.1 % W/w + Clobetasol 0.05 % W/w + Chlorocresol 0.1 % W/w Cream

Apply a thin layer to the affected area as directed by the physician. Clean and dry the affected skin before application. Wash hands before and after use. Avoid contact with eyes, mouth, or open wounds.

Store below 25–30°C. Protect from heat and moisture. Keep the tube tightly closed. Keep out of reach of children.

Common side effects include: Burning or stinging sensation Skin irritation Redness or dryness

Use with caution in: Children Large areas of skin Long-term use

Use only for the duration prescribed by a doctor. Prolonged use of clobetasol may cause skin thinning or hormonal effects. Avoid covering the treated area with airtight bandages unless advised. Do not apply on face or sensitive areas unless prescribed. If symptoms do not improve within a few days, consult a doctor.

OTC Product Information: clotrimazole topical cream 1%, clotrimazole topical cream 1%. Akron Pharma Inc, Fairfiled, NJ, as posted to the DailyMed site 1/2022. 10. Product Information: Clotrimazole topical solution 1%, clotrimazole topical solution 1%. AvKare (per DailyMed), Pulaski, TN, 2025. British National Formulary (BNF), Latest Edition – Topical Antifungals and Corticosteroids. Product Information: gentamicin sulfate 0.1% topical ointment, gentamicin sulfate 0.1% topical ointment. E. Fougera & Co, Melville, NY, 2008. Product Information: TEMOVATE E(R) topical emollient cream, clobetasol propionate topical emollient cream. GlaxoSmithKline Consumer Healthcare LP, Pittsburgh, PA, 2002.

Clotrimazole inhibits fungal cytochrome P450–dependent 14-α-demethylase, impairing ergosterol synthesis and disrupting fungal cell membrane integrity. Tolnaftate interferes with squalene epoxidase activity, inhibiting fungal cell membrane synthesis. Iodochlorhydroxyquinoline exhibits antimicrobial effects through metal chelation and inhibition of microbial enzymes. Gentamicin binds irreversibly to the 30S ribosomal subunit of susceptible bacteria, inhibiting protein synthesis. Clobetasol propionate exerts anti-inflammatory and immunosuppressive effects via glucocorticoid receptor activation, leading to inhibition of inflammatory mediators and cytokines.

Topical Antifungal