Dapagliflozin 10 Mg + Vildagliptin (sr) 100 Mg + Metformin Hydrochloride (sr) 500 Mg

It is typically taken orally, once daily, with a meal or as directed by a healthcare professional. Swallow the tablet or extended-release tablet whole with a full glass of water. Do not crush, break, or chew it. While taking the extended-release tablet, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Common side effects may include urinary tract infections, genital yeast infections, increased urination, diarrhea, nausea, vomiting, headache, or dizziness, difficulty in urination

Acute or chronic metabolic acidosis including diabetic ketoacidosis Severe renal impairment Avoid use of this drug during pregnancy and prescribe an alternative. Evidence has demonstrated fetal abnormalities or risks when used during pregnancy. Advise women of childbearing potential of fetal risk.

Avoid alcohol and tobaccco consumption while taking this medicnes Vildagliptin Sr 100 Mg + Dapagliflozin 10 Mg Tablet should not be used in patients with type 1 diabetes mellitus or diabetic ketoacidosis. Hyperglycemia (high blood sugar) may occur if you do not take enough or skip a dose of your medicine, overeat or do not follow your meal plan, have a fever or infection, or do not exercise as much as usual. High blood sugar can be very serious and must be treated right away. It is important that you learn which symptoms you have in order to treat it quickly. Talk to your doctor about the best way to treat high blood sugar. Dizziness, lightheadedness, or fainting may occur with this medicine. Drink plenty of water during exercise or in hot weather. Check with your doctor if you have severe nausea, vomiting, or diarrhea that does not stop. This may cause you to lose too much water.

Product Information: GLUCOPHAGE(R) oral tablets, metformin HCl oral tablets. Bristol-Myers Squibb Company (per FDA), Princeton, NJ, 2017. Product Information: Metformin Juta oral tablet, metformin hydrochloride oral tablet. Juta Pharma GmbH (per AEMPS;Spain), Gutenbergstrasse 13, 24941 Flensburg, Germany, 2019. Product Information: FORXIGA(R) oral tablets, dapagliflozin oral tablets. AstraZeneca Pharmaceuticals LP (per manufacturer), Wilmington, DE, 2021. Dandona P, Mathieu C, Phillip M, et al: Efficacy and safety of dapagliflozin in patients with inadequately controlled type 1 diabetes (DEPICT-1): 24 week results from a multicentre, double-blind, phase 3, randomised controlled trial. Lancet Diabetes Endocrinol 2017; 5(11):864-876. Product Information: Jalra oral tablets, vildagliptin oral tablets. Novartis Europharm Limited (per EMA), Camberley, United Kingdom, 2015. Product Information: Galvus oral tablets, vildagliptin oral tablets. Novartis Europharm Limited (per EMA), Camberley, United Kingdom, 2016.

Dapagliflozin 10 mg: Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It works by inhibiting SGLT2 in the kidneys, which reduces glucose reabsorption and promotes the excretion of glucose in the urine. This helps lower blood sugar levels in people with type 2 diabetes. Metformin Hydrochloride 500 mg SR: Metformin is a biguanide antidiabetic medication. It works by decreasing the production of glucose in the liver, reducing intestinal glucose absorption, and increasing glucose uptake and utilization in peripheral tissues. Metformin SR (sustained-release) formulations release the medication gradually over time, allowing for once-daily dosing. Vildagliptin inhibits the enzyme DPP-4, which leads to increased levels of active incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). These hormones stimulate insulin secretion and inhibit glucagon release in a glucose-dependent manner, thereby improving glycemic control.

Anti Diabetic