Glibenclamide 5 Mg

Glibenclamide is an anti-diabetic drug. Glibenclamide tablets are used in the management of non-insulin dependent diabetes to lower the level of sugar in the blood. They are used in cases where diet alone does not provide sufficient control.

The starting dose is 5 mg a day, taken during or straight after breakfast (or the first main meal of the day). This may then be adjusted by your doctor, to a maximum of 15 mg a day Always take Glibenclamide exactly as your doctor has told you.

Keep out of the reach and sight of children. Do not store above 25ºC. Keep in the original package or container supplied. Do not transfer them to another container. Do not use Glibenclamide after the expiry date that is stated on the outer packaging.

Like all medicines, Glibenclamide can cause side effects, although not everybody gets them. • an allergic reaction (swelling of the lips, face or neck leading to severe difficulty in breathing; skin rash or hives). This is a very serious but rare side effect.

Do NOT take Glibenclamide if you: • are allergic (hypersensitive) to Glibenclamide or any of the other ingredients of this medicine • have a serious problems with your kidneys, liver, adrenal glands or pituitary gland • are about to undergo any form of surgery • have a severe infection • have porphyria (Symptoms you may feel are like abdominal pain, mental confusion, anxiety, fits, muscle pain etc.) • have juvenile or insulin-dependent diabetes • are in trauma or suffering from stress. • suffering from a history of diabetic ketoacidosis (presence of ketones in the urine) or diabetic coma or pre-coma. • are elderly (Age over 70 years). These tablets should not be used in patients suffering from or with a history of diabetic ketoacidosis (presence of ketones in the urine) or diabetic coma

Talk to your doctor before you start to take this medicine if you: • are weak or feeble as you are more likely to suffer from a “hypo” (low blood-sugar attack) • have a controlled diet or you take less calorie food or glucose • have irregular meal time or you miss your meals often • are doing excessive exercise • If you have G6PD- deficiency (G6PD is an enzyme which protects red blood cells in blood). Please speak to your doctor if you are not sure about it. • are debilitated. • have lapp lactose deficiency (you are unable to digest milk or milk product) • have mild to moderate kidney problems. If you have jaundice (yellowing of skin and whites of the eyes) then please discontinue this medicine. Speak to your doctor in this case. Do NOT use Glibenclamide if you are pregnant or planning to become pregnant. Speak to your doctor before taking any medicine. You should let your doctor know as soon a

https://www.drugs.com/uk/glibenclamide-5mg-tablets-leaflet FDA Drug Label – Glyburide (Glibenclamide), DailyMed Database. American Diabetes Association. Standards of Medical Care in Diabetes. Diabetes Care. Isselbacher KJ, Braunwald E, Wilson JD, et al (Eds): Harrison's Principles of Internal Medicine, 13th. McGraw-Hill, Inc., New York, NY, 1994.

Glibenclamide binds to the sulfonylurea receptor (SUR1) subunit of ATP-sensitive potassium (KATP) channels on pancreatic β-cells, causing channel closure and membrane depolarization. This leads to opening of voltage-dependent calcium channels, increased intracellular calcium influx, and subsequent insulin secretion from pancreatic β-cells.

Anti Diabetic