Product Details
GLIMEPIRIDE 2 MG + PIOGLITAZONE HCL 15 + METFORMIN HYDROCHLORIDE 500 MG SR
Introduction : This combination of Glimepiride 2 Mg + Pioglitazone Hcl 15 + Metformin 500 Mg SR (sustained release) tablet is indicated for the treatment of type 2 diabetes mellitus in adults when diet, exercise, and single-agent therapy with metformin or a sulfonylurea do not provide adequate glycemic control.
Indication : Glimepiride 2 Mg + Pioglitazone Hcl 15 + Metformin 500 Mg SR (sustained release) tablet is a medicine that helps to control high blood glucose (sugar) levels. It helps get rid of extra glucose from your body through urine. It also improves the body?s response to the hormone insulin, which is responsible for regulating blood glucose (sugar) levels in our body. The insulin helps to lower your blood glucose levels and prevents them from rising after taking meals. You should keep taking it for as long as it is prescribed.
Lowering blood glucose levels is an essential part of managing diabetes. If you can control the level you will reduce the risk of getting any of the serious complications of diabetes such as kidney damage, eye damage, nerve problems, and loss of limbs. Taking this medicine regularly along with proper diet and exercise will help you live a normal, healthy life.
Administration : Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet before swallowing, as this may affect the sustained-release properties of the formulation.
It is typically taken orally, usually once or twice daily with meals to reduce the risk of gastrointestinal side effects.
Storage : Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Mechanism of Action : Glimepiride: Glimepiride belongs to the sulfonylurea class of medications and works by stimulating insulin release from pancreatic beta cells, thereby lowering blood glucose levels.
Pioglitazone: Pioglitazone is a thiazolidinedione (TZD) that improves insulin sensitivity in peripheral tissues such as muscle and adipose tissue, leading to increased glucose uptake and reduced hepatic glucose production.
Metformin Hydrochloride SR: Metformin is a biguanide that primarily works by decreasing hepatic glucose production, increasing insulin sensitivity in peripheral tissues, and reducing intestinal glucose absorption.
Therapeutic : Anti Diabetic
Side Effects : Common side effects of this combination medication may include hypoglycemia (low blood sugar), weight gain, edema (fluid retention), gastrointestinal disturbances (such as nausea, vomiting, diarrhea), headache, and dizziness.
Contraindications : "If you are pregnant, ask your doctor for advice before taking this
medicine.
You must not take this medicine while you are breast-feeding"
Safety Advice / Warnings : This medicine be used with caution in elderly patients, as they may be more susceptible to hypoglycemia and other adverse effects.
Patients should be advised to avoid excessive alcohol consumption while taking this tablet, as alcohol may potentiate the risk of hypoglycemia.
Tablets are not recommended for use during pregnancy.
If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this
medicine.
You must not take this medicine while you are breast-feeding
Drinking alcohol is not recommended as it can alter the control of your diabetes in an unpredictable manner"
References : Bressler R & Johnson DG: Pharmacological regulation of blood glucose levels in non-insulin-dependent diabetes mellitus. Arch Intern Med 1997; 157:836-848.
Product Information: GLUMETZA(R) oral extended-release tablets, metformin HCl oral extended-release tablets. Valeant Pharmaceuticals of North America (per FDA), Bridgewater, NJ, 2017.
Metformin Hydrochloride SR, Pioglitazone Hydrochloride and Glimepiride Tablets [Prescribing Information]. Ahmedabad, Gujarat: Torrent Pharmaceuticals Ltd.; 2016. [Accessed 27 Oct. 2021]