Product Details
SITAGLIPTIN 50 MG + METFORMIN 500 MG
Introduction : Sitagliptin 50mg + Metformin 500mg combination tablets are indicated for the treatment of type 2 diabetes mellitus in adults when diet and exercise alone do not provide adequate glycemic control.
Sitagliptin 50mg reduces blood sugar levels by increasing the amount of insulin made and released from pancreas, and also decreases the amount sugar made by liver.
Metformin 500mg works by decreasing the production of glucose in the liver, reducing intestinal glucose absorption, and increasing glucose uptake and utilization in peripheral tissues.
Indication : Sitagliptin 50mg + Metformin 500mg combination tablets is prescribed for the management of type 2 diabetes mellitus in adults. It helps control blood sugar levels by increasing insulin release from the pancreas and reducing glucose production by the liver, ultimately improving glycemic control.
Sitagliptin 50mg + Metformin 500mg combination tablets are used as an adjunct to diet and exercise when these measures alone are insufficient to control blood sugar levels in patients with type 2 diabetes mellitus. The combination therapy provides additional glycemic control beyond what can be achieved with lifestyle modifications alone.
Administration : Typically, one tablet is taken orally with meals once or twice daily, as prescribed by the healthcare provider.
Storage : Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Mechanism of Action : Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by increasing the levels of incretin hormones, which stimulate the release of insulin from the pancreas and decrease the secretion of glucagon, thereby reducing blood sugar levels.
Metformin belongs to the biguanide class of medications. It works by decreasing glucose production by the liver, decreasing intestinal glucose absorption, and improving insulin sensitivity in peripheral tissues.
Therapeutic : Anti Diabetic
Side Effects : may include nausea, vomiting, diarrhea, stomach upset, headache, and hypoglycemia (low blood sugar).
Contraindications : Avoid use of this drug during pregnancy and prescribe an alternative. Evidence has demonstrated fetal abnormalities or risks when used during pregnancy. Advise women of childbearing potential of fetal risk.
Acute or chronic metabolic acidosis including diabetic ketoacidosis
Severe renal impairment
Safety Advice / Warnings : This medicine may cause serious allergic reactions, including anaphylaxis, angioedema, or certain skin conditions.
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to decide if you should continue to take it.
This medicine may cause hypoglycemia (low blood sugar). This is more common when this medicine is taken together with certain medicines. Low blood sugar must be treated before it causes you to pass out (unconsciousness). Talk to your doctor about the best way to treat low blood sugar.
Avoid alcohol and tobaccco consumption while taking this medicnes
References : Product Information: Disit 50MG oral tablet, sitagliptin hydrochloride monohydrate 50MG oral tablet. Laboratorios Alter, SA (per AEMPS;Spain), C/Mateo Inurria 30, 28036 Madrid, Spain, 2019.
Product Information: ZITUVIO oral tablets, sitagliptin oral tablets. Zydus Pharmacuticals (USA) Inc (per FDA), Pennington, NJ, 2023.
Product Information: GLUCOPHAGE(R) oral tablets, metformin HCl oral tablets. Bristol-Myers Squibb Company (per FDA), Princeton, NJ, 2017.