Product Details
ATORVASTATIN 10 MG + EZETIMIBE 10 MG
Introduction : Ezetimibe 10mg and atorvastatin 10mg tablet combination is used together with a proper diet to treat high cholesterol and triglyceride (fats) levels in the blood. This medicine may help prevent medical problems (eg, heart attack, stroke) caused by clogged blood vessels. It is also used to treat a condition called homozygous familial hypercholesterolemia (HoFH).
Ezetimibe is a cholesterol absorption inhibitor and atorvastatin is an HMG-CoA reductase inhibitor, or statin. These medicines will reduce the absorption of cholesterol from foods and the production of cholesterol in your body.
This medicine was available only with your doctors prescription.
Indication : This combination of Ezetimibe 10mg and atorvastatin 10mg tablet medication is typically prescribed for the management of hypercholesterolemia (high levels of cholesterol in the blood) and for reducing the risk of cardiovascular events in patients with dyslipidemia.
Administration : Dosage and administration should be determined by a healthcare professional based on the individual patients condition and response to treatment.
Advise patient to take at the same time every day with a full glass of water
Storage : Store the medicine at room temperature, away from heat, moisture, and direct light.
Keep out of the reach of children.
Mechanism of Action : Atorvastatin decreases cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and hepatic cholesterol synthesis, and increases the number of cell surface LDL-C receptors in the liver to increase uptake and catabolism of LDL-C.
Ezetimibe reduces cholesterol by blocking its absorption in the small intestine via the sterol transporter, Nieman-Pick C1-Like 1, which transports cholesterol and phytosterols from the intestine. Decreased cholesterol absorption from the small intestine reduces hepatic cholesterol stores and increases cholesterol clearance
Therapeutic : Anti Hyperlipidemic
Side Effects : Drug may cause joint or extremity pain, coughing, bronchitis, sinusitis, or abdominal pain
Headache
Muscle pain (myalgia)
Abdominal pain
Diarrhea
Fatigue
Dizziness
Elevated liver enzymes
Contraindications : Avoid use of this drug during pregnancy, Evidence has demonstrated fetal abnormalities or risks when used during pregnancy and breastfeeding..
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Safety Advice / Warnings : Do not drink large amounts of alcohol with this medicine. This could cause unwanted effects on the liver
Using this medicine while you are pregnant can harm your unborn baby
Check with your doctor right away if you have dark-colored urine, fever, muscle cramps or spasms, muscle pain or stiffness, or unusual tiredness or weakness
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
References : Renew JR: Perioperative management of hyperlipidemia medications. Curr Clin Pharmacol 2017; 12(3):152-156.
Product Information: LIPTRUZET(R) oral tablets, ezetimibe atorvastatin oral tablets. Merck Sharp & Dohme Corp. (per FDA), Whitehouse Station, NJ, 2014.
Ezetimibe/Atorvastatin Cinfamed oral tablet, ezetimibe/atorvastatin oral tablet. Laboratorios Cinfa, SA (per AEMPS;Spain), Olaz-Chipi Highway, 31620 Huarte (Navarra), Spain, 2019.