Product Details
ROSUVASTATIN 20 MG + CLOPIDOGREL 75 MG
Introduction : The combination of Rosuvastatin 20mg + Clopidogrel 75mg tablet is used to reduce the risk of cardiovascular events such as heart attack, stroke, and cardiovascular death in patients at high risk of cardiovascular disease. It may be prescribed for individuals with a history of myocardial infarction, stroke, peripheral arterial disease, or coronary artery disease to prevent further cardiovascular events and improve long-term outcomes.
Indication : Rosuvastatin 20mg is a statin medication that effectively reduces cholesterol levels in the blood
Clopidogrel 75mg is an antiplatelet medication that prevents blood clot formation by inhibiting platelet aggregation
A heart attack or stroke may occur when a blood vessel is blocked by a blood clot. Clopidogrel 75mg reduces the chance that a harmful blood clot will form by preventing platelets from clumping together in the blood.
Rosuvastatin is used together with a proper diet to lower bad cholesterol (LDL) and triglycerides (fats) in the blood, and to increase your good cholesterol (HDL)
Administration : "You may take this medicine with or without food.
Swallow the tablet whole. Do not break, crush, or chew it.
To use the capsule:
Swallow the capsule whole. Do not crush or chew it. If you have trouble swallowing, you may open it and mix the contents with 1 teaspoon of soft food. Take this mixture within 1 hour, without chewing."
Storage : Store the medication at room temperature, away from moisture, heat, and direct sunlight.
Side Effects : Gastrointestinal disturbances such as nausea, vomiting, or diarrhea
Headache
Muscle pain or weakness
Increased risk of bleeding (especially with clopidogrel)
Liver enzyme abnormalities
Allergic reactions
Rash
Contraindications : "Avoid use of this drug during pregnancy and prescribe an alternative. Evidence has demonstrated fetal abnormalities or risks when used during pregnancy.
Evidence and/or expert consensus has demonstrated harmful infant effects when used during breastfeeding.
""Active pathological bleeding, including peptic ulcer or intracranial hemorrhage [16]
Hypersensitivity (eg, anaphylaxis) to clopidogrel, rosuvastatin or any component of the product"""
Safety Advice / Warnings : Patients taking Rosuvastatin + Clopidogrel should be monitored regularly for signs of bleeding, liver function abnormalities, and muscle-related side effects.
Clopidogrel should be used with caution in patients with a history of bleeding disorders or peptic ulcer disease.
If you need to take an antacid that contains aluminum and magnesium, take the antacid at least 2 hours after using rosuvastatin.
Do not drink large amounts of alcohol while using rosuvastatin. This could cause side effects on the liver.
Avoid eating grapefruit or drinking grapefruit juice while using this medication
References : Product Information: PLAVIX(R) oral tablets, clopidogrel bisulfate oral tablets. Bristol-Myers Squibb/Sanofi Pharmaceuticals Partnership (per FDA), Bridgewater, NJ, 2021
Product Information: CRESTOR(R) oral tablets, rosuvastatin calcium oral tablets. AstraZeneca Pharmaceuticals LP (per FDA), Wilmington, DE, 2023.
Micromedex drug Information database
Mechanism of Action : Rosuvastatin 20 mg: Rosuvastatin is a statin medication used to lower cholesterol levels in the blood. It works by inhibiting the enzyme HMG-CoA reductase, which plays a key role in cholesterol production in the liver.
Clopidogrel 75 mg: Clopidogrel is an antiplatelet medication that helps prevent blood clots by inhibiting platelet aggregation. It does this by blocking the P2Y12 receptor on platelets, thereby reducing their ability to stick together and form clots.
Therapeutic : Hyperlipidemic