Product Details
TELMISARTAN 40 MG + CHLORTHALIDONE 6.25 MG + CILNIDIPINE 10 MG
Introduction : This combination medication of Telmisartan 40Mg , Chlorthalidone 6.25 Mg & Cilnidipine 10 Mg is indicated for the treatment of hypertension (high blood pressure) in adults.
Hypertension is a condition characterized by elevated blood pressure levels persistently above normal. Uncontrolled hypertension can lead to serious complications such as heart disease, stroke, and kidney damage.
This medication is prescribed to help lower blood pressure and reduce the risk of associated cardiovascular events.
Indication : Telmisartan 40Mg , Chlorthalidone 6.25 Mg & Cilnidipine 10 Mg tablet is indicated for the treatment of hypertension (high blood pressure) in adults.
In cases where hypertension is difficult to control with a single medication, combination therapy may be necessary. This combination of Telmisartan, Chlorthalidone, and Cilnidipine offers a synergistic approach by targeting different pathways involved in blood pressure regulation. It may be particularly beneficial for patients with resistant hypertension, where blood pressure remains elevated despite treatment with multiple antihypertensive agents.
Administration : Administer orally with or without food, as directed by the healthcare provider.
Dosage may vary depending on individual patient factors and as prescribed by a healthcare professional.
Storage : Store the medication at room temperature, away from moisture and heat.
Keep it out of reach of children
Mechanism of Action : Telmisartan: It is an angiotensin II receptor blocker (ARB). Telmisartan selectively blocks the binding of angiotensin II to the angiotensin II type 1 (AT1) receptor, leading to vasodilation and reduction in blood pressure.
Chlorthalidone: It is a thiazide diuretic. Chlorthalidone inhibits sodium reabsorption in the distal convoluted tubules of the kidney, leading to increased excretion of sodium and water and subsequent reduction in blood volume and blood pressure.
Cilnidipine: It is a calcium channel blocker with dual action on L-type and N-type calcium channels. Cilnidipine causes vasodilation by inhibiting calcium influx into vascular smooth muscle cells, resulting in decreased peripheral vascular resistance and blood pressure.
Therapeutic : Cardiovascular Agent
Side Effects : Dizziness
Headache
Fatigue
Hypotension (low blood pressure)
Electrolyte disturbances (such as hypokalemia)
Increased uric acid levels
Renal impairment
Gastrointestinal disturbances (such as nausea, vomiting, and diarrhea)
Contraindications : Evidence has demonstrated harmful infant effects when used during breastfeeding.
Avoid use of this drug during pregnancyy.
Safety Advice / Warnings : This medication combination should be used with caution in patients with impaired liver or kidney function.
Patients should be monitored regularly for signs of hypotension, especially when initiating therapy or adjusting the dosage.
Do report symptoms of potassium loss
Side effects may include hypotension, dizziness, and renal dysfunction
Do not drink alcohol while taking this drug, as this may aggravate hypotension.
Dizziness, lightheadedness, or even fainting may occur when you get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem.
References : Product Information: Telmisartan. Boehringer Ingelheim, US, 98.
Beermann B & Groschinsky-Grind MG: Clinical pharmacokinetics of diuretics. Clin Pharmacokinet 1980; 5:221-245.
Product Information: Chlorthalidone oral tablets, chlorthalidone oral tablets. Sun Pharmaceutical Industries Inc (per DailyMed), Cranbury, NJ, 2017.
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