Product Details
KETOCONAZOLE 2.0% w/w CREAM
Introduction : Ketoconazole 2.0% cream is used to treat infections caused by a fungus or yeast. It works by killing the fungus or yeast or preventing its growth.
Ketoconazole cream is used to treat:
Athletes foot (tinea pedis; ringworm of the foot);
Ringworm of the body (tinea corporis);
Ringworm of the groin (tinea cruris; jock itch);
Seborrheic dermatitis;
"Sun fungus" (tinea versicolor; pityriasis versicolor); and
Yeast infection of the skin (cutaneous candidiasis).
Indication : Ketoconazole 2.0% cream may also be used for other fungus infections of the skin as determined by your doctor.
Ketoconazole cream is also used to manage cutaneous candidiasis, a fungal infection caused by Candida species, which commonly affects moist areas of the skin, such as the groin, armpits, and skin folds. It helps alleviate symptoms such as redness, itching, and rash associated with candidiasis.
Administration : This medicine is for use on the skin only.
Do not get it in your eyes, nose, mouth, or vagina. Do not use it on skin areas that have cuts, scrapes, or burns. If it does get on these areas, rinse it off right away with water.
Storage : Store the medicine at room temperature, away from heat, moisture, and direct light.
Mechanism of Action : Ketoconazole, the active ingredient in ketoconazole cream, is an antifungal medication that works by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes. By disrupting fungal cell membrane integrity, ketoconazole prevents the growth and replication of fungal organisms, ultimately leading to their eradication.
Therapeutic : Anti fungal
Side Effects : Skin irritation
Burning sensation
Itching
Redness
Dryness
Peeling of the skin
Contraindications : Evidence has demonstrated harmful infant effects when used during breastfeeding.
Safety Advice / Warnings : Good health habits are also required for patients using the cream form of this medicine to help clear up your infection completely and to help make sure it does not return.
For patients using the cream for athletes foot (tinea pedis; ringworm of the foot), the following instructions will help keep the feet cool and dry:
Avoid wearing socks made from wool or synthetic materials (e.g., rayon or nylon). Instead, wear clean, cotton socks and change them daily or more often if your feet sweat a lot.
Wear sandals or well-ventilated shoes (e.g., shoes with holes).
Use a bland, absorbent powder (e.g., talcum powder) or an antifungal powder between the toes, on the feet, and in socks and shoes one or two times a day. It is best to use the powder between the times you use the cream.
For patients using the cream for ringworm of the groin (tinea cruris; jock itch), the following instructions will help reduce irritation and will also help keep the groin area cool and dry:
Avoid wearing underwear that is tight-fitting or made from synthetic materials (e.g., rayon or nylon). Instead, wear loose-fitting, cotton underwear.
Use a bland, absorbent powder (e.g., talcum powder) or an antifungal powder on the skin. It is best to use the powder between the times you use ketoconazole cream.
References : Product Information: XOLEGEL(R) topical gel, ketoconazole topical gel. Aqua Pharmaceuticals, LLC (per FDA), San Antonio, TX, 2012.
Heel RC, Brogden RN, Carmine A, et al: Ketoconazole: a review of its therapeutic efficacy in superficial and systemic fungal infections. Drugs 1982; 23:1-36.