Sitagliptin 25 Mg

Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure

Store the medicine in a closed packing at room temperature, away from heat, moisture, and direct light. Keep out of the reach of children.

Most common adverse reactions (incidence≥5%) are upper respiratory tract infection , nasopharyngitis and headache.

Product Information: Disit 50MG oral tablet, sitagliptin hydrochloride monohydrate 50MG oral tablet. Laboratorios Alter, SA (per AEMPS;Spain), C/Mateo Inurria 30, 28036 Madrid, Spain, 2019. Product Information: ZITUVIO oral tablets, sitagliptin oral tablets. Zydus Pharmacuticals (USA) Inc (per FDA), Pennington, NJ, 2023. Micromedex Drug Information Database.

Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) enzyme inhibitor. The activity of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) is limited by the enzyme DPP-4, which rapidly hydrolyzes incretin hormones to form inactive products. Sitagliptin prevents the hydrolysis of incretin hormones by DPP-4, thereby increasing plasma concentrations of the active forms of GLP-1 and GIP. By stimulating the levels of active incretins sitagliptin increases insulin release and reduces glucagon levels with glucose-dependent behavior. The glucose-dependent sitagliptin mechanism is different from the sulfonylureas mechanism, which increases insulin secretion even when glucose levels are low and can lead to hypoglycemia in patients with type 2 diabetes and normal patients.

DIABETIC