Product Details
DICLOFENAC 50 MG + PARACETAMOL 325 MG + CHLOROXAZONE 250 MG
Introduction : This combination medication typically contains three active ingredients: diclofenac 50mg, paracetamol 325mg (acetaminophen), and chlorzoxazone 250mg. It is often used to provide relief from pain and inflammation associated with musculoskeletal conditions.
Diclofenac 50mg is also used to treat acute migraine attacks, with or without aura, in adults. It will not prevent or lessen the number of migraine attacks.
The combination is used when a dual mechanism of pain relief and anti-inflammatory action is required, such as in conditions involving musculoskeletal pain and inflammation.
Chlorzoxazone 250mg is a muscle relaxant that acts directly on the central nervous system to relieve muscle spasms and stiffness. It works by inhibiting the reflexes in the spinal cord, reducing muscle contractions and promoting muscle relaxation. This helps in easing the discomfort associated with muscle spasms, strains, sprains, and other muscular conditions.
Indication : This combination medication typically contains three active ingredients:diclofenac 50mg, paracetamol 325mg (acetaminophen), and chlorzoxazone 250mg. It is often used to provide relief from pain and inflammation associated with musculoskeletal conditions.
Diclofenac: Provides anti-inflammatory and analgesic effects, reducing pain associated with conditions such as osteoarthritis and rheumatoid arthritis.
Chlorzoxazone: Acts centrally to relax muscles, providing relief from muscle spasms, stiffness, and associated pain.
Paracetamol: Aids in reducing fever, providing additional relief in conditions associated with elevated body temperature.
Administration : "Dosage should be determined by a healthcare professional based on the specific condition being treated and the patients individual needs.
Storage : Store the medication as directed on the packaging, typically at room temperature away from light and moisture.
Mechanism of Action : Diclofenac is an NSAID with potent antiinflammatory, analgesic, and antipyretic properties [8]. Like other NSAIDs, although the mechanism is not completely understood, it may involve inhibition of prostaglandin synthetase and COX-1 and COX-2 pathways
The mechanism of action of acetaminophen in reducing pain is unknown but may be due to an inhibition of central prostaglandin synthesis (specifically cyclooxygenase (COX)-2) and an elevation of the pain threshold. Acetaminophen reduces fever by inhibiting the formulation and release of prostaglandins in the CNS and by inhibition endogenous pyrogens at the hypothalamic thermoregulator center
Side Effects : Side effects may include dizziness, headache, edema, abdominal pain, constipation, nausea, vomiting, diarrhea, dyspepsia, pruritus, and extremity pain
Contraindications : Contraindicated in patients with known hypersensitivity to any of the components, severe liver or kidney disease, gastrointestinal bleeding, and certain other conditions.
Contraindicated in individuals with a history of hypersensitivity to diclofenac, paracetamol, or other NSAIDs.
Avoid in patients with active peptic ulcers, severe heart failure, and certain bleeding disorders.
Safety Advice / Warnings : NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use
Regular monitoring of liver function tests is advisable, especially with prolonged use of paracetamol.
Caution is advised in patients with pre-existing liver conditions.
Always take medications as prescribed by your healthcare provider and consult with them for any concerns or questions regarding your treatment. This information is provided for general knowledge and does not replace professional medical advice.
References : Product Information: ZORVOLEX(TM) oral capsules, diclofenac oral capsules. Iroko Pharmaceuticals, LLC (per manufacturer), Philadelphia, PA, 2013.
Willkens RF: Worldwide clinical safety experience with diclofenac. Semin Arthritis Rheum 1985; 15(suppl 1):105-110.
Product Information: Paracetamol Aristogen 1000MG oral tablet, paracetamol 1000MG oral tablet. Aristo Pharma GmbH (per AEMPS;Spain), Wallenroder strabe 8-10, 13435 Berlin, Germany, 2019.