Clopidogrel 75 Mg

You may take this medicine with or without food. If you are also taking omeprazole ) or esomeprazole , do not use it at the same time that you take this medicine. Talk with your doctor about using a different antacid. Your doctor may tell you to take aspirin while you are using clopidogrel. Do not change the dose or stop taking the aspirin without talking to your doctor first.

Store in a cool and dry place away from sunlight

Side effects may include rash, pruritus, colitis, diarrhea, hepatotoxicity, itching, pain, redness, or swelling

Active pathological bleeding, including peptic ulcer or intracranial hemorrhage Hypersensitivity (eg, anaphylaxis) to clopidogrel or any component of the product

While you are using this medicine, if you have any kind of bleeding, it may take longer than usual to stop, especially if you hurt yourself. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Be careful when using sharp objectsincluding razors and fingernail clippers. Avoid use of this drug during pregnancy and prescribe an alternative. Evidence has demonstrated fetal abnormalities or risks when used during pregnancy. Evidence and/or expert consensus has demonstrated harmful infant effects when used during breastfeeding. Avoid eating grapefruit or drinking grapefruit juice while using this medication. If you are also taking omeprazole ) or esomeprazole do not use it at the same time that you take this medicine. Talk with your doctor about using a different antacid.

Product Information: PLAVIX(R) oral tablets, clopidogrel bisulfate oral tablets. Bristol-Myers Squibb/Sanofi Pharmaceuticals Partnership (per FDA), Bridgewater, NJ, 2021. Product Information: Zyllt oral tablet, clopidogrel oral tablet. KRKA, DD, Novo Mesto (per AEMPS;Spain), 2019. Product Information: Cupido oral tablet, clopidogrel oral tablet. Apotex (per SFDA; Saudi Arabia), 2019.

Clopidogrel bisulfate is a thienopyridine class inhibitor of CYP2Y12 adenosine diphosphate (ADP) platelet receptors. Clopidogrel must be metabolized by CYP450 enzymes to produce its active metabolite. The active metabolite selectively and irreversibly inhibits the binding of ADP to its platelet P2Y12 receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. Consequently, platelets exposed to the active metabolite are affected for the remainder of their lifespan (about 7 to 10 days). Platelet aggregation induced by agonists other than ADP is also inhibited by blocking the amplification of platelet activation by released ADP.

CARDIAC