Product Details
ESOMEPRAZOLE MAGNESIUM 40 MG + LEVOSULPIRIDE 75 MG SR
Introduction : This combination of ESOMEPRAZOLE MAGNESIUM 40 + LEVOSULPIRIDE 75 MG SR (Sustained Release) medication is typically prescribed for the treatment of gastroesophageal reflux disease (GERD), peptic ulcers, dyspepsia, and other acid-related disorders.
Esomeprazole helps relieve symptoms of acid reflux and promotes healing of esophageal or gastric ulcers.
Levosulpiride aids in improving gastrointestinal motility and reducing symptoms such as bloating, nausea, and abdominal discomfort.
Indication : This ESOMEPRAZOLE MAGNESIUM 40 + LEVOSULPIRIDE 75 MG SR CAPSULE is a prescription medicine used in the treatment of gastroesophageal reflux disease (acid reflux). It works by relieving the symptoms such as heartburn, stomach pain, or irritation. It also neutralizes the acid production in the stomach to prevent discomfort.
Administration : It is usually taken orally without food, once daily in the morning or as directed by a healthcare professional.
Storage : Store the medication at room temperature, away from moisture, heat, and direct sunlight.
Mechanism of Action : Esomeprazole reduces gastric acid secretion by irreversibly binding to the proton pump (H+/K+ ATPase) in gastric parietal cells, thereby inhibiting the final step of acid production.
Levosulpiride acts as a dopamine D2 receptor antagonist in the gastrointestinal tract, increasing the release of acetylcholine and enhancing gastrointestinal motility, which helps alleviate symptoms of dyspepsia and GERD.
Therapeutic : Gastrointestinal Agent
Side Effects : Common Side Effects:
Dry mouth
Headache
Dizziness
Abdominal cramps
breast pain/tenderness, rash, pruritus, diarrhea, somnolence.
Contraindications : ESOMEPRAZOLE MAGNESIUM 40 + LEVOSULPIRIDE 75 MG SR is CONTRAINDICATED in patients with known allergies to esomeprazole or levosulpiride and who have Parkinsons disease, severe renal or hepatic insufficiency, epilepsy, porphyrias, breast cancer, or hypokalemia.
Safety Advice / Warnings : Esomeprazole + Levosulpiride is not recommended during pregnancy and while breastfeeding.
Taking this medicine for a long time may make it harder for your body to absorb vitamin B12. Tell your doctor if you have concerns about vitamin B12 deficiency.
Serious stomach conditions may occur while taking this medicine alone or together with antibiotics. Check with your doctor immediately
This medicine may cause hypomagnesemia (low magnesium in the blood). This is more likely to occur if you are using this medicine for more than one year, or if you are using it together with digoxin (Lanoxin?) or certain diuretics (water pills).
References : Product Information: NEXIUM(R) oral delayed-release capsules, suspension, esomeprazole magnesium oral delayed-release capsules, suspension. AstraZeneca Pharmaceuticals LP (per FDA), Wilmington, DE, 2020.
Product Information: Nexium oral tablet, esomeprazole oral tablet. AstraZeneca AB (per SFDA; Saudi Arabia), 2017.
ScienceDirect. Levosulpiride. [Accessed 12 Apr. 2019] (online) (https://www.sciencedirect.com/topics/neuroscience/levosulpiride)