Esomeprazole Magnesium 40 Mg + Levosulpiride 75 Mg Sr

It is usually taken orally without food, once daily in the morning or as directed by a healthcare professional.

Store the medication at room temperature, away from moisture, heat, and direct sunlight.

Common Side Effects: Dry mouth, Headache, Dizziness, Abdominal cramps, breast pain/tenderness, rash, pruritus, diarrhea, somnolence.

ESOMEPRAZOLE MAGNESIUM 40 + LEVOSULPIRIDE 75 MG SR is CONTRAINDICATED in patients with known allergies to esomeprazole or levosulpiride and who have Parkinson's disease, severe renal or hepatic insufficiency, epilepsy, porphyrias, breast cancer, or hypokalemia.

Esomeprazole + Levosulpiride is not recommended during pregnancy and while breastfeeding. Taking this medicine for a long time may make it harder for your body to absorb vitamin B12. Tell your doctor if you have concerns about vitamin B12 deficiency. Serious stomach conditions may occur while taking this medicine alone or together with antibiotics. Check with your doctor immediately This medicine may cause hypomagnesemia (low magnesium in the blood). This is more likely to occur if you are using this medicine for more than one year, or if you are using it together with digoxin (Lanoxin®) or certain diuretics (water pills).

Product Information: NEXIUM(R) oral delayed-release capsules, suspension, esomeprazole magnesium oral delayed-release capsules, suspension. AstraZeneca Pharmaceuticals LP (per FDA), Wilmington, DE, 2020. Product Information: Nexium oral tablet, esomeprazole oral tablet. AstraZeneca AB (per SFDA; Saudi Arabia), 2017. ScienceDirect. Levosulpiride. [Accessed 12 Apr. 2019] (online) (https://www.sciencedirect.com/topics/neuroscience/levosulpiride)

Esomeprazole reduces gastric acid secretion by irreversibly binding to the proton pump (H+/K+ ATPase) in gastric parietal cells, thereby inhibiting the final step of acid production. Levosulpiride acts as a dopamine D2 receptor antagonist in the gastrointestinal tract, increasing the release of acetylcholine and enhancing gastrointestinal motility, which helps alleviate symptoms of dyspepsia and GERD.

Gastrointestinal Agent