Product Details
GLIPIZIDE 5 MG + METFORMIN HYDROCHLORIDE 500 MG
Introduction : Glipizide 5 Mg + Metformin 500 Mg tablet is indicated for the treatment of type 2 diabetes mellitus in adults, particularly when blood sugar levels are not adequately controlled by diet and exercise alone. It helps to lower blood sugar levels by addressing different aspects of glucose metabolism:
Glipizide stimulates insulin release from the pancreas, thereby reducing blood sugar levels.
Metformin decreases glucose production in the liver, improves insulin sensitivity in peripheral tissues, and reduces intestinal glucose absorption.
Indication : Glipizide 5 Mg + Metformin 500 Mg tablet is primarily prescribed for the management of type 2 diabetes mellitus. It helps control blood sugar levels by addressing multiple aspects of glucose metabolism.
Glipizide 5 Mg + Metformin 500 Mg combination medication is also used to reduce the risk of long-term complications associated with diabetes, such as cardiovascular disease, neuropathy, nephropathy, and retinopathy. By maintaining stable blood sugar levels and improving insulin sensitivity, this medication helps mitigate the adverse effects of hyperglycemia on various organs and tissues in the body.
Administration : The dosage of Glipizide 5 Mg + Metformin 500 Mgmay vary depending on the patients blood sugar levels
It is typically taken orally, Patient should take tablet 30 min before a meal, preferably breakfast.
Storage : Keep this medicine out of the sight and reach of children.
? Do not store above 25C. Store in the original package
Mechanism of Action : Metformin reduces hepatic glucose production, enhances peripheral glucose uptake and utilization, and decreases intestinal glucose absorption.
GlipiZIDE is an oral hypoglycemic drug belonging to the sulfonylurea class. It acts by stimulating insulin secretion from functioning beta cells in the pancreas, especially in response to a meal. It may also increase insulin sensitivity and lower hepatic glucose production
Therapeutic : Anti Diabetic
Side Effects : Hypoglycemia (low blood sugar)
Gastrointestinal symptoms such as nausea, diarrhea, or abdominal discomfort
Headache
Dizziness
Weight gain (less common with metformin)
Contraindications : "If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this
medicine.
You must not take this medicine while you are breast-feeding"
Safety Advice / Warnings : "This medicine be used with caution in elderly patients, as they may be more susceptible to hypoglycemia and other adverse effects.
Patients should be advised to avoid excessive alcohol consumption while taking Glipizide, as alcohol may potentiate the risk of hypoglycemia.
Tablets are not recommended for use during pregnancy.
If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this
medicine.
You must not take this medicine while you are breast-feeding
Drinking alcohol is not recommended as it can alter the control of your diabetes in an unpredictable manne
References : Product Information: GLUMETZA(R) oral extended-release tablets, metformin HCl oral extended-release tablets. Valeant Pharmaceuticals of North America (per FDA), Bridgewater, NJ, 2017.
Bressler R & Johnson DG: Pharmacological regulation of blood glucose levels in non-insulin-dependent diabetes mellitus. Arch Intern Med 1997; 157:836-848.
Product Information: GLUCOTROL(R) oral tablets, glipizide oral tablets. Roerig, New York, NY, 2009.
Wahlin-Boll E, Almer LO, & Melander A: Bioavailability, pharmacokinetics and effects of glipizide in type 2 diabetics. Clin Pharmacokinet 1982; 7:363.