Esomeprazole 40 + Domperidone 30 Mg Sr

Esomeprazole 40 mg + Domperidone 30 mg SR (Sustained Release) is a combination medication that typically consists of two active ingredients: esomeprazole, a proton pump inhibitor (PPI), and domperidone, a dopamine receptor antagonist. This combination is often prescribed for the treatment of certain gastrointestinal conditions. Esomeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as heartburn, difficulty swallowing, and cough. This medication helps heal acid damage to the stomach and esophagus, helps prevent ulcers. Domperidone is a medicine that increases the movements or contractions of the stomach and bowel. Domperidone is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson's Disease. Domperidone is to be given only by or under the immediate supervision of your doctor.

Take this medicine at least 1 hour before a meal and for the full time of treatment, even if you begin to feel better after a few days.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Common Side Effects: Dry mouth, Headache, Dizziness, Abdominal cramps, breast pain/tenderness, rash, pruritus, diarrhea, somnolence, or loss of libido.

Avoid use of this drug during pregnancy and prescribe an alternative. Evidence has demonstrated fetal abnormalities or risks when used during pregnancy. Evidence has demonstrated harmful infant effects when used during breastfeeding.

Esomeprazole may cause a serious type of allergic reaction when used in patients with conditions treated with antibiotics. Call your doctor right away if you or your child has itching, trouble breathing or swallowing, or any swelling of your hands, face, or mouth. Taking this medicine for a long time may make it harder for your body to absorb vitamin B12. Tell your doctor if you have concerns about vitamin B12 deficiency. Serious stomach conditions may occur while taking this medicine alone or together with antibiotics. Check with your doctor immediately This medicine may cause hypomagnesemia (low magnesium in the blood). This is more likely to occur if you are using this medicine for more than one year, or if you are using it together with digoxin (Lanoxin®) or certain diuretics (water pills).

Product Information: NEXIUM(R) oral delayed-release capsules, suspension, esomeprazole magnesium oral delayed-release capsules, suspension. AstraZeneca Pharmaceuticals LP (per FDA), Wilmington, DE, 2020. Product Information: Nexium oral tablet, esomeprazole oral tablet. AstraZeneca AB (per SFDA; Saudi Arabia), 2017. Product Information: Dismotil oral tablets, domperidone oral tablets. Co-pharma Ltd (per MHRA), Watford, Hertfordshire, United Kingdom, 2014. Product Information: MOTILIUM 10 oral film coated tablets, domperidone oral film coated tablets. McNeil Products Limited (per MHRA), Maidenhead, Berkshire, United Kingdom, 2013.

Esomeprazole magnesium, a proton pump inhibitor, blocks the final step in acid production by specific inhibition of the H(+)/K(+)-ATPase in the gastric parietal cell, thus suppressing gastric acid secretion Domperidone is a dopamine antagonist that does not cross the blood brain barrier. Its antiemetic activity may be related to its ability to increase lower esophageal pressure, improve antroduodenal motility, and speed gastric emptying. Antiemetic activity may also be related to dopamine receptor antagonism at the chemoreceptor trigger zone located in the area postrema, which is outside the blood brain barrier.

Gastrointestinal Agent